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Split-sciatic nerve surgery: A new microsurgical model in experimental nerve repair

Schiraldi, Luigi
Sottaz, Lima
Madduri, Srinivas
Campisi, Corrado
Oranges, Carlo M
Raffoul, Wassim
di Summa, Pietro G
Published in Journal of plastic, reconstructive & aesthetic surgery. 2018, vol. 71, no. 4, p. 557-565
Abstract Sciatic experimental surgery in rat often leads to hindlimb autophagy, with considerable ethical and research issues. In this work, the distal part of the sciatic nerve was split following the natural bifurcation between tibial and peroneal branches, before applying regenerative stem cells in a fibrin conduit on the peroneal segment. The new microsurgical model was tested in terms of animal morbidity and consistency of research outcomes, particularly comparing to the standard total sciatic axotomy procedure.
Keywords Axonal regenerationMicrosurgical modelPeripheral nerve surgeryRegenerative medicineStem cells
PMID: 29229422
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Article (Published version) (2.5 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Reconstruction chirurgicale et régénération des tissus (1029)
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SCHIRALDI, Luigi et al. Split-sciatic nerve surgery: A new microsurgical model in experimental nerve repair. In: Journal of Plastic, Reconstructive & Aesthetic Surgery, 2018, vol. 71, n° 4, p. 557-565. doi: 10.1016/j.bjps.2017.11.007

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Deposited on : 2021-09-27

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