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Scientific article
English

Is routine measurement of the serum C-reactive protein level helpful during antibiotic therapy for diabetic foot infection?

Published inDiabetes, Obesity and Metabolism, vol. 23, no. 2, p. 637-641
Publication date2021
Abstract

Clinicians frequently monitor serum C-reactive protein (CRP) levels during therapy for diabetic foot infections (DFIs), but evidence supporting this is unclear. Using a database from prospective controlled DFI trials, with fixed duration of antibiotic therapy, we correlated the CRP levels at study enrolment and at end of therapy (EOT). Among 159 DFI episodes, 93 involved the bone and 66 the soft tissues. Overall, treatment cured 122 infections (77%), while 37 episodes (23%) recurred after a median of 53 days. The median CRP in the groups with cure versus failure differed minimally at enrolment (median 67 vs. 81 mg/L) or EOT (7 vs. 10 mg/L). Similarly, there was negligible difference in the percentage of CRP levels that normalized at EOT (39% vs. 35%). In our prospective cohorts, a blunt iterative monitoring of CRP during DFI treatment, without correlation with clinical findings, failed to predict treatment failures.

Keywords
  • CRP
  • Diabetic foot infection
  • Failure
  • Follow-up
  • Prospective side-study
  • Recurrence
  • Therapy
Citation (ISO format)
PHAM, Truong-Thanh et al. Is routine measurement of the serum C-reactive protein level helpful during antibiotic therapy for diabetic foot infection? In: Diabetes, Obesity and Metabolism, 2021, vol. 23, n° 2, p. 637–641. doi: 10.1111/dom.14222
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ISSN of the journal1462-8902
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Creation03/23/2021 11:23:00 AM
First validation03/23/2021 11:23:00 AM
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