Scientific article
Case report

Immune-mediated retinopathy in a patient with stiff-man syndrome

Published inGraefe's Archive for Clinical and Experimental Ophthalmology, vol. 237, no. 3, p. 212-219
Publication date1999

Stiff-man syndrome is a rare neurological disorder characterised by rigidity and violent spasms of the body musculature. In the majority of patients, presence of antibodies against glutamic acid decarboxylase (GAD), the enzyme synthesizing gamma-aminobutyric acid (GABA), suggests an autoimmune attack against GABA-ergic inhibitory neurons. We report a 32-year-old patient with stiff-man syndrome and anti-GAD antibodies who developed subacute progressive loss of vision in the right eye, and in the left eye 18 months thereafter.

  • Adult
  • Autoantibodies/analysis
  • Autoantigens/immunology
  • Autoimmune Diseases/enzymology/immunology/physiopathology
  • Biomarkers
  • Disease Progression
  • Electroretinography
  • Evoked Potentials
  • Visual
  • Fluorescein Angiography
  • Fluorescent Antibody Technique
  • Indirect
  • Follow-Up Studies
  • Glutamate Decarboxylase/immunology
  • Humans
  • Retina/enzymology/immunology/pathology
  • Retinal Diseases/enzymology/immunology/physiopathology
  • Stiff-Person Syndrome/enzymology/immunology/physiopathology
  • Visual Acuity
Affiliation Not a UNIGE publication
Citation (ISO format)
STEFFEN, Heimo et al. Immune-mediated retinopathy in a patient with stiff-man syndrome. In: Graefe’s Archive for Clinical and Experimental Ophthalmology, 1999, vol. 237, n° 3, p. 212–219. doi: 10.1007/s004170050221
Main files (1)
Article (Published version)
ISSN of the journal0721-832X

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