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Scientific article
English

Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina

Published inCurrent Gene Therapy, vol. 22, no. 2, p. 168-183
Publication date2022
Abstract

Non-viral transposon-mediated gene delivery can overcome viral vectors' limitations. Transposon gene delivery offers the safe and life-long expression of genes such as pigment epithelium-derived factor (PEDF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) to counteract retinal degeneration by reducing oxidative stress damage.

Keywords
  • Sleeping beauty transposon
  • PEDF
  • GM-CSF
  • Age-related macular degeneration
  • RPE cells
  • Non-viral gene delivery
  • oxidative stress damage
  • Ocular gene therapy
Citation (ISO format)
BASCUAS CASTILLO, Thaïs et al. Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina. In: Current Gene Therapy, 2022, vol. 22, n° 2, p. 168–183. doi: 10.2174/1566523221666210707123809
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Article (Published version)
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Article (Published version)
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Identifiers
ISSN of the journal1566-5232
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Technical informations

Creation09/14/2021 4:08:00 PM
First validation09/14/2021 4:08:00 PM
Update time03/16/2023 1:20:09 AM
Status update03/16/2023 1:20:08 AM
Last indexation01/17/2024 2:16:32 PM
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