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Title

Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina

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Published in Current Gene Therapy. 2021
Abstract Non-viral transposon-mediated gene delivery can overcome viral vectors' limitations. Transposon gene delivery offers the safe and life-long expression of genes such as pigment epithelium-derived factor (PEDF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) to counteract retinal degeneration by reducing oxidative stress damage.
Keywords Sleeping beauty transposonPEDFGM-CSFAge-related macular degenerationRPE cellsNon-viral gene deliveryoxidative stress damageOcular gene therapy
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PMID: 34238157
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Research group Ophtalmologie expérimentale (925)
Project
FNS: 31003A_160195/1
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BASCUAS CASTILLO, Thaïs et al. Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina. In: Current Gene Therapy, 2021. doi: 10.2174/1566523221666210707123809 https://archive-ouverte.unige.ch/unige:154850

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Deposited on : 2021-09-21

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