Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina

Bascuas Castillo, Thaïs; Zedira, Hajer; Kropp, Martina; Harmening, Nina; Asrih, Mohamed; Prat-Souteyrand, Cécile; Tian, Shuwei; Thumann, Gabriele

doi:10.2174/1566523221666210707123809

Scientific article

English

Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina

ContributorsBascuas Castillo, Thaïs; Zedira, Hajer; Kropp, Martina; Harmening, Nina; Asrih, Mohamed; Prat-Souteyrand, Cécile; Tian, Shuwei; Thumann, Gabriele

Published inCurrent Gene Therapy, vol. 22, no. 2, p. 168-183

Publication date2022

Abstract

Non-viral transposon-mediated gene delivery can overcome viral vectors' limitations. Transposon gene delivery offers the safe and life-long expression of genes such as pigment epithelium-derived factor (PEDF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) to counteract retinal degeneration by reducing oxidative stress damage.

Keywords

Sleeping beauty transposon
PEDF
GM-CSF
Age-related macular degeneration
RPE cells
Non-viral gene delivery
oxidative stress damage
Ocular gene therapy

Affiliation

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Research group

Ophtalmologie expérimentale (925)

Funding

Swiss National Science Foundation - Transposon Based Gene Cell Therapy In The Treatment Of Dry Macular Degeneration [31003A_160195]

Citation (ISO format)

BASCUAS CASTILLO, Thaïs et al. Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina. In: Current Gene Therapy, 2022, vol. 22, n° 2, p. 168–183. doi: 10.2174/1566523221666210707123809

Article (Published version)

Article (Published version)

Identifiers

PID : unige:154850
DOI : 10.2174/1566523221666210707123809
PMID : 34238157

Datasets

https://doi.org/10.26037/yareta:nknjbdlqwrc7perfksgofnskm4

ISSN of the journal1566-5232

328views

60downloads

Creation14.09.2021 16:08:00

First validation14.09.2021 16:08:00

Update time16.03.2023 01:20:09

Status update16.03.2023 01:20:08

Last indexation17.01.2024 14:16:32

Archive ouverte UNIGE

Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina

Technical informations