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Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina

ContributorsBascuas Castillo, Thaïsorcid; Zedira, Hajer; Kropp, Martinaorcid; Harmening, Nina; Asrih, Mohamed; Prat-Souteyrand, Cécile; Tian, Shuwei; Thumann, Gabrieleorcid
Published inCurrent Gene Therapy, vol. 22, no. 2, p. 168-183
Publication date2022
Abstract

Non-viral transposon-mediated gene delivery can overcome viral vectors' limitations. Transposon gene delivery offers the safe and life-long expression of genes such as pigment epithelium-derived factor (PEDF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) to counteract retinal degeneration by reducing oxidative stress damage.

Keywords
  • Sleeping beauty transposon
  • PEDF
  • GM-CSF
  • Age-related macular degeneration
  • RPE cells
  • Non-viral gene delivery
  • oxidative stress damage
  • Ocular gene therapy
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Citation (ISO format)
BASCUAS CASTILLO, Thaïs et al. Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina. In: Current Gene Therapy, 2022, vol. 22, n° 2, p. 168–183. doi: 10.2174/1566523221666210707123809
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Journal ISSN1566-5232
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Creation14/09/2021 18:08:00
First validation14/09/2021 18:08:00
Update time16/03/2023 02:20:09
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