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Scientific article
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French

Atelier d'harmonisations 2019 : indications et organisation d'une microtransplantation de cellules souches hématopoïétiquesIndications and management of hematologic microtransplantation: Recommendations of the French Society of Bone Marrow transplantation and cellular Therapy (SFGM-TC)

Published inBulletin du cancer, vol. 107, no. 12, p. 139-139
Publication date2020
Abstract

Microtransplantation (MT) is based on injection of HLA-mismatched G-CSF mobilized hematopoietic stem cells, in combination with chemotherapy but without use of conditioning regimen nor immunosuppressive drugs. As a result, a transient microchimerism is induced without engraftment. Its efficacy relies both on host immune system stimulation (recipient versus tumor) and on a graft versus tumor effect. Data are scarce and concern mostly Asian patients with acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (HR-MDS). In comparison to conventional treatment without MT, higher complete remission rates and longer disease free survival and overall survival have been reported. Safety seems acceptable. The most frequent adverse event is non-severe cytokine release syndrome. Risk of GVHD remains very low. Here, we summarize the published data and detail the practical aspects of the procedure. Current data are not strong enough to provide recommendations on indications. Nevertheless, it seems reasonable to propose MT to patients with AML or HR-MDS, regardless of age, presenting an indication for allogeneic stem cell transplantation but ineligible for it. MT is still under investigation and rather be proposed within clinical trials.

Keywords
  • Microtransplantation
  • Leucémie aiguë
  • Atelier
NoteRecommendations of the French Society of Bone Marrow transplantation and cellular Therapy (SFGM-TC)
Citation (ISO format)
CORNILLON, Jérôme et al. Atelier d’harmonisations 2019 : indications et organisation d’une microtransplantation de cellules souches hématopoïétiquesIndications and management of hematologic microtransplantation: Recommendations of the French Society of Bone Marrow transplantation and cellular Therapy (SFGM-TC). In: Bulletin du cancer, 2020, vol. 107, n° 12, p. 139–139. doi: 10.1016/j.bulcan.2020.03.016
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ISSN of the journal0007-4551
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