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Scientific article
English

Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT

Published inBritish Journal of Haematology, vol. 190, no. 3, p. 437-441
Publication date2020
Abstract

Myeloproliferative Neoplasm (MPN), unclassifiable (MPN-U) is a heterogeneous disease with regards to both clinical phenotype and disease course. Patients may initially be asymptomatic or present with leucocytosis or thrombocytosis, anaemia, progressive splenomegaly, constitutional symptom, thromboses or accelerated/blastic phase disease. Treatment strategies are variable and there are no widely accepted consensus management guidelines for MNU-U. Allogeneic Haematopoietic Cell Transplantation (allo-HCT) remains the only curative strategy yet outcomes, to date, are not well defined. We hereby report on the largest retrospective study of patients with MPN-U undergoing allo-HCT, highlighting the potentially curative role and providing clinicians with robust engraftment, GvHD and outcome data to facilitate patient discussion.

Keywords
  • Allogeneic stem cell transplant
  • Conditioning
  • Myeloproliferative neoplasms unclassifiable
  • Non-relapse mortality
Citation (ISO format)
MCLORNAN, Donal P et al. Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT. In: British Journal of Haematology, 2020, vol. 190, n° 3, p. 437–441. doi: 10.1111/bjh.16537
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ISSN of the journal0007-1048
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