Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT.

McLornan, Donal P; Malpassuti, Vittoria; Lippinkhof-Kozijn, Anne; Potter, Victoria; Beelen, Dietrich; Bunjes, Donald; Sengeloev, Henrik; Radujkovic, Aleksandar; Passweg, Jakob; Chalandon, Yves; Kröger, Nicolaus; Wulf, Gerald G; Johansson, Jan-Erik; Ciceri, Fabio; Bornhäuser, Martin; Holler, Ernst; Guffroy, Blandine; Martin, Sonja; Neubauer, Andreas; Gramatski, Martin; Robin, Marie; Iacobelli, Simona; Hayden, Patrick; Hernández Boluda, Juan C; Czerw, Tomasz; Yakoub-Agha, Ibrahim

doi:10.1111/bjh.16537

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT.
Authors		McLornan, Donal P Malpassuti, Vittoria Lippinkhof-Kozijn, Anne Potter, Victoria Beelen, Dietrich Bunjes, Donald Sengeloev, Henrik Radujkovic, Aleksandar Passweg, Jakob Chalandon, Yves Kröger, Nicolaus Wulf, Gerald G Johansson, Jan-Erik Ciceri, Fabio Bornhäuser, Martin Holler, Ernst Guffroy, Blandine Martin, Sonja Neubauer, Andreas Gramatski, Martin Robin, Marie Iacobelli, Simona Hayden, Patrick Hernández Boluda, Juan C Czerw, Tomasz Yakoub-Agha, Ibrahim show all authors [1 - 26]
Published in		British journal of haematology. 2020, vol. 190, no. 3, p. 437-441
Abstract		Myeloproliferative Neoplasm (MPN), unclassifiable (MPN-U) is a heterogeneous disease with regards to both clinical phenotype and disease course. Patients may initially be asymptomatic or present with leucocytosis or thrombocytosis, anaemia, progressive splenomegaly, constitutional symptom, thromboses or accelerated/blastic phase disease. Treatment strategies are variable and there are no widely accepted consensus management guidelines for MNU-U. Allogeneic Haematopoietic Cell Transplantation (allo-HCT) remains the only curative strategy yet outcomes, to date, are not well defined. We hereby report on the largest retrospective study of patients with MPN-U undergoing allo-HCT, highlighting the potentially curative role and providing clinicians with robust engraftment, GvHD and outcome data to facilitate patient discussion.
Keywords		Allogeneic stem cell transplant — Conditioning — Myeloproliferative neoplasms unclassifiable — Non-relapse mortality
Identifiers		DOI: 10.1111/bjh.16537 PMID: 32108327
Full text		Article (Published version) (189 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
Citation (ISO format)		MCLORNAN, Donal P et al. Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT. In: British Journal of Haematology, 2020, vol. 190, n° 3, p. 437-441. doi: 10.1111/bjh.16537 https://archive-ouverte.unige.ch/unige:154830