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Title

Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT.

Authors
McLornan, Donal P
Malpassuti, Vittoria
Lippinkhof-Kozijn, Anne
Potter, Victoria
Beelen, Dietrich
Bunjes, Donald
Sengeloev, Henrik
Radujkovic, Aleksandar
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Published in British journal of haematology. 2020, vol. 190, no. 3, p. 437-441
Abstract Myeloproliferative Neoplasm (MPN), unclassifiable (MPN-U) is a heterogeneous disease with regards to both clinical phenotype and disease course. Patients may initially be asymptomatic or present with leucocytosis or thrombocytosis, anaemia, progressive splenomegaly, constitutional symptom, thromboses or accelerated/blastic phase disease. Treatment strategies are variable and there are no widely accepted consensus management guidelines for MNU-U. Allogeneic Haematopoietic Cell Transplantation (allo-HCT) remains the only curative strategy yet outcomes, to date, are not well defined. We hereby report on the largest retrospective study of patients with MPN-U undergoing allo-HCT, highlighting the potentially curative role and providing clinicians with robust engraftment, GvHD and outcome data to facilitate patient discussion.
Keywords Allogeneic stem cell transplantConditioningMyeloproliferative neoplasms unclassifiableNon-relapse mortality
Identifiers
PMID: 32108327
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Research group Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
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MCLORNAN, Donal P et al. Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT. In: British Journal of Haematology, 2020, vol. 190, n° 3, p. 437-441. doi: 10.1111/bjh.16537 https://archive-ouverte.unige.ch/unige:154830

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Deposited on : 2021-09-20

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