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Scientific article
Review
Open access
English

Cytokines of the IL-17 family in psoriasis

Published inJournal der Deutschen Dermatologischen Gesellschaft, vol. 18, no. 7, p. 675-681
Publication date2020
Abstract

Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL-17 family are of particular importance. In addition to IL-17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL-17 family also have a proinflammatory effect. This review provides an up-to-date overview of the immunopathogenesis of psoriasis with regard to the six IL-17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.

Keywords
  • Antibodies
  • Monoclonal
  • Humanized/therapeutic use
  • Humans
  • Interleukin-17/chemistry/physiology
  • Psoriasis/drug therapy/immunology
  • Receptors
  • Interleukin-17/physiology
Citation (ISO format)
LAUFFER, Felix et al. Cytokines of the IL-17 family in psoriasis. In: Journal der Deutschen Dermatologischen Gesellschaft, 2020, vol. 18, n° 7, p. 675–681. doi: 10.1111/ddg.14124
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Article (Published version)
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ISSN of the journal1610-0379
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