en
Scientific article
English

Interest of cytogenetic and FISH evaluation for prognosis evaluation in 198 patients with acute myeloid leukemia in first complete remission in a single institution

Published inLeukemia Research, vol. 38, no. 8, p. 907-912
Publication date2014
Abstract

The prognostic interest of cytogenetic remission and fluorescent in situ hybridization (FISH) evaluation in patients with abnormal karyotype acute myeloid leukemia (AML) has been poorly studied. Among 198 patients that reached complete remission (CR), 24 did not reach cytogenetic remission (CyCR). CyCR had no prognosis impact, especially in patients with intermediate or unfavorable cytogenetic. Twenty of 52 evaluated patients in CyCR did not reach FISH CR. FISH CR was associated with better OS (p=0.004) and tended to be associated with better disease-free survival (DFS) (p=0.08). FISH evaluation may be a useful tool for prognosis evaluation and minimal residual disease (MRD) assessment in patients with abnormal cytogenetic AML.

Keywords
  • AML
  • Cytogenetic remission
  • FISH
  • Prognosis
Affiliation Not a UNIGE publication
Citation (ISO format)
HIRSCH, Pierre et al. Interest of cytogenetic and FISH evaluation for prognosis evaluation in 198 patients with acute myeloid leukemia in first complete remission in a single institution. In: Leukemia Research, 2014, vol. 38, n° 8, p. 907–912. doi: 10.1016/j.leukres.2014.05.021
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0145-2126
108views
0downloads

Technical informations

Creation10/28/2020 2:15:00 PM
First validation10/28/2020 2:15:00 PM
Update time03/16/2023 1:18:18 AM
Status update03/16/2023 1:18:16 AM
Last indexation01/17/2024 2:14:28 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack