Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient

Schnepf, Nathalie; Dhédin, Nathalie; Mercier-Delarue, Séverine; Andreoli, Annalisa; Mamez, Anne-Claire; Ferry, Christelle; Deback, Claire; Ribaud, Patricia; Robin, Marie; Socié, Gérard; Simon, François; Mazeron, Marie-Christine

doi:10.1016/j.jcv.2013.10.007

Scientific article

Case report

English

Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient

ContributorsSchnepf, Nathalie; Dhédin, Nathalie; Mercier-Delarue, Séverine; Andreoli, Annalisa; Mamez, Anne-Claire; Ferry, Christelle; Deback, Claire; Ribaud, Patricia; Robin, Marie; Socié, Gérard; Simon, François; Mazeron, Marie-Christine

Published inJournal of Clinical Virology, vol. 58, no. 4, p. 733-736

Publication date2013

Abstract

We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depend on both the selection pressure exerted by the antiviral treatments and the immune response.

Keywords

Adult
Antiviral Agents/therapeutic use
Cytomegalovirus/genetics
Cytomegalovirus Infections/drug therapy/virology
Drug Resistance, Viral/genetics
Female
Genes, Viral
Hematopoietic Stem Cell Transplantation
Humans
Mutation
Young Adult

Affiliation entities

Not a UNIGE publication

Research groups

Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)

Citation (ISO format)

SCHNEPF, Nathalie et al. Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient. In: Journal of Clinical Virology, 2013, vol. 58, n° 4, p. 733–736. doi: 10.1016/j.jcv.2013.10.007

Article (Published version)

Identifiers

PID : unige:154737
DOI : 10.1016/j.jcv.2013.10.007
PMID : 24183928

Additional URL for this publicationhttps://www.sciencedirect.com/science/article/pii/S1386653213004253

Journal ISSN1386-6532

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Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient

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