en
Scientific article
Case report
English

Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient

Published inJournal of Clinical Virology, vol. 58, no. 4, p. 733-736
Publication date2013
Abstract

We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depend on both the selection pressure exerted by the antiviral treatments and the immune response.

Keywords
  • Adult
  • Antiviral Agents/therapeutic use
  • Cytomegalovirus/genetics
  • Cytomegalovirus Infections/drug therapy/virology
  • Drug Resistance, Viral/genetics
  • Female
  • Genes, Viral
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Mutation
  • Young Adult
Affiliation Not a UNIGE publication
Citation (ISO format)
SCHNEPF, Nathalie et al. Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient. In: Journal of Clinical Virology, 2013, vol. 58, n° 4, p. 733–736. doi: 10.1016/j.jcv.2013.10.007
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Article (Published version)
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Identifiers
ISSN of the journal1386-6532
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