Scientific article
Case report

Right diaphragmatic palsy as a cause of QRS alternans

Published inEuropean Heart Journal, vol. 41, no. 21, 2039
Publication date2020

Loss of body mass and exercise intolerance are common findings in chronic obstructive pulmonary disease and are often difficult to reverse despite optimal nutritional intake. Similar findings have been reported in healthy individuals during high-altitude exposure. The role of hypoxia in modulating metabolism has been largely investigated in vitro and in animal studies. More fragmentary is the knowledge regarding hypoxia effects on in-vivo human metabolism. This paper reviews recent literature regarding the effects of chronic exposure to hypoxia on metabolism, particularly comparing chronic obstructive pulmonary disease patients with humans exposed to high altitude.

  • Altitude
  • Animals
  • Chronic Disease
  • Cytokines/metabolism
  • DNA-Binding Proteins/metabolism
  • Energy Metabolism/physiology
  • Exercise/physiology
  • Gene Expression Regulation
  • Humans
  • Hypoxia/metabolism/physiopathology
  • Hypoxia-Inducible Factor 1
  • Alpha Subunit
  • Muscle
  • Skeletal/physiopathology
  • Nuclear Proteins/metabolism
  • Oxygen/physiology
  • Pulmonary Disease
  • Chronic Obstructive/metabolism/physiopathology
  • Transcription Factors/metabolism
Citation (ISO format)
JOHNER, Nicolas et al. Right diaphragmatic palsy as a cause of QRS alternans. In: European Heart Journal, 2020, vol. 41, n° 21, p. 2039. doi: 10.1093/eurheartj/ehaa244
Main files (1)
Article (Published version)
ISSN of the journal0195-668X

Technical informations

Creation10/22/2020 9:20:00 AM
First validation10/22/2020 9:20:00 AM
Update time03/16/2023 1:16:17 AM
Status update03/16/2023 1:16:16 AM
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