Simultaneous management of blood flow and IOP in glaucoma

Harris, A; Jonescu-Cuypers, Christian Paul; Martin, B; Kagemann, L; Zalish, M; Garzozi, H J

doi:10.1034/j.1600-0420.2001.079004336.x

Scientific article

Review

English

Simultaneous management of blood flow and IOP in glaucoma

Contributors

Harris, A; Jonescu-Cuypers, Christian Paul; Martin, B; Kagemann, L; Zalish, M; Garzozi, H J

Published in

Acta Ophthalmologica Scandinavica, vol. 79, no. 4, p. 336-341

Publication date

2001

Abstract

Factors other than intraocular pressure (IOP) elevation must be involved in initiation and progression of glaucoma. An additional element in disease causation may be ischemia in the retina and optic nerve head. Ischemic damage to neurons in the CNS is similar mechanistically and histopathologically to changes seen in glaucoma. Further, glaucoma patients with normal IOP show clear evidence for cerebral and ocular ischemia. Aging and atherosclerosis reduce the ability of the eye to autoregulate blood flow when ocular perfusion pressure changes: the dependence of blood flow on perfusion pressure links ischemia to IOP. Consequently, neuroprotective treatments for glaucoma should be designed to both reduce IOP and improve ocular nutrient delivery.

Keywords

Aging/physiology
Arteriosclerosis/physiopathology
Blood Flow Velocity/physiology
Glaucoma/physiopathology
Homeostasis/physiology
Humans
Intraocular Pressure
Ischemia/physiopathology
Regional Blood Flow/physiology
Retinal Vessels/physiopathology

UNIGE affiliation entities

Not a UNIGE publication

UNIGE research groups

Ophtalmologie expérimentale (925)

Citation (ISO format)

HARRIS, A et al. Simultaneous management of blood flow and IOP in glaucoma. In: Acta Ophthalmologica Scandinavica, 2001, vol. 79, n° 4, p. 336–341. doi: 10.1034/j.1600-0420.2001.079004336.x

Article (Published version)

Identifiers

PID : unige:154264
DOI : 10.1034/j.1600-0420.2001.079004336.x
PMID : 11453850

Additional URL for this publication

https://onlinelibrary.wiley.com/doi/full/10.1034/j.1600-0420.2001.079004336.x?sid=nlm%3Apubmed

Journal ISSN

1395-3907

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206downloads

Creation

24/08/2021 11:18:00

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24/08/2021 11:18:00

Update

16/03/2023 01:10:16

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16/03/2023 01:10:15

Last indexation

31/10/2024 22:55:49

Simultaneous management of blood flow and IOP in glaucoma

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation