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Scientific article
English

Cholinergic inhibition by botulinum toxin in a rat model of congenital glaucoma raises intraocular pressure

Published inBritish Journal of Ophthalmology, vol. 92, no. 6, p. 826-831
Publication date2008
Abstract

Cholinergic receptors are crucially involved in the regulation of intraocular pressure (IOP). Muscarinic agonists in the trabecular meshwork tissue increase aqueous humour outflow facility by a direct stimulation of ciliary muscle contraction. We investigated the contribution of cholinergic state to IOP regulation.

Keywords
  • Animals
  • Biomarkers/analysis
  • Blotting
  • Western/methods
  • Botulinum Toxins
  • Type A/pharmacology
  • Choline O-Acetyltransferase/analysis
  • Cholinergic Antagonists/pharmacology
  • Depression
  • Chemical
  • Disease Models
  • Animal
  • Female
  • Glaucoma/genetics/physiopathology
  • Immunohistochemistry
  • Intraocular Pressure/drug effects
  • Rats
  • Rats
  • Mutant Strains
  • Rats
  • Sprague-Dawley
  • Trabecular Meshwork/drug effects/enzymology
Affiliation Not a UNIGE publication
Citation (ISO format)
GATZIOUFAS, Z et al. Cholinergic inhibition by botulinum toxin in a rat model of congenital glaucoma raises intraocular pressure. In: British Journal of Ophthalmology, 2008, vol. 92, n° 6, p. 826–831. doi: 10.1136/bjo.2007.128033
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0007-1161
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