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Scientific article
Case report
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Primary extra-osseous ewing sarcoma of the thyroid: a case report and review of the literature

Publication date2021
Abstract

Extra-osseous Ewing sarcoma (ES) is a rare and aggressive malignant tumor found in a variety of organs. Primary ES of the thyroid is exceedingly rare and few cases have been documented to date. We describe the case of a 54-year old woman with a history of breast carcinoma in whom a unique hypermetabolic left thyroid nodule was identified during a follow-up PET-CT scan. An ultrasound examination showed a hypoechogenic nodule of 3.7 cm. A cytological diagnosis of poorly differentiated thyroid carcinoma was made, and a total thyroidectomy was performed. The surgical specimen revealed a poorly differentiated neoplasm composed of medium-sized cells with scant cytoplasm, expressing pancytokeratin, CD99 and NKX2.2 but lacking p63 and p40 expression. Molecular analysis revealed a EWSR1-FLI1 fusion transcript supporting the diagnosis of a primary extra-osseous ES of the thyroid. The patient received adjuvant chemotherapy and has no evidence of recurrent disease.

Citation (ISO format)
SEIPEL, Amanda et al. Primary extra-osseous ewing sarcoma of the thyroid: a case report and review of the literature. In: Head and Neck Pathology, 2021. doi: 10.1007/s12105-021-01365-x
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ISSN of the journal1936-055X
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Creation08/09/2021 4:22:00 PM
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