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Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design

Jelescu, Ileana
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Published in Alzheimer's research & therapy. 2021, vol. 13, no. 1, 105
Abstract Subjective cognitive decline (SCD) is the subjective perception of a decline in memory and/or other cognitive functions in the absence of objective evidence. Some SCD individuals however may suffer from very early stages of neurodegenerative diseases (such as Alzheimer's disease, AD), minor psychiatric conditions, neurological, and/or somatic comorbidities. Even if a theoretical framework has been established, the etiology of SCD remains far from elucidated. Clinical observations recently lead to the hypothesis that individuals with incipient AD may have overestimated metacognitive judgements of their own cognitive performance, while those with psychiatric disorders typically present underestimated metacognitive judgements. Moreover, brain connectivity changes are known correlates of AD and psychiatric conditions and might be used as biomarkers to discriminate SCD individuals of different etiologies. The aim of the COSCODE study is to identify metacognition, connectivity, behavioral, and biomarker profiles associated with different etiologies of SCD. Here we present its rationale and study design.
Keywords Alzheimer's disease biomarkersConnectivityMetacognitionSubjective cognitive decline
PMID: 34034799
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Research groups Ischémie cérébrale et connectivité (801)
Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984)
Troubles de mémoire et maladie d'Alzeimer (935)
Swiss National Science Foundation: 320030_182772
Swiss National Science Foundation: 320030_169876
Swiss National Science Foundation: 320030_185028
(ISO format)
RIBALDI, Federica et al. Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design. In: Alzheimer's Research and Therapy, 2021, vol. 13, n° 1, p. 105. doi: 10.1186/s13195-021-00846-z https://archive-ouverte.unige.ch/unige:153742

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Deposited on : 2021-08-05

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