Scientific article
Open access

Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design

Published inAlzheimer's Research and Therapy, vol. 13, no. 1, 105
Publication date2021

Subjective cognitive decline (SCD) is the subjective perception of a decline in memory and/or other cognitive functions in the absence of objective evidence. Some SCD individuals however may suffer from very early stages of neurodegenerative diseases (such as Alzheimer's disease, AD), minor psychiatric conditions, neurological, and/or somatic comorbidities. Even if a theoretical framework has been established, the etiology of SCD remains far from elucidated. Clinical observations recently lead to the hypothesis that individuals with incipient AD may have overestimated metacognitive judgements of their own cognitive performance, while those with psychiatric disorders typically present underestimated metacognitive judgements. Moreover, brain connectivity changes are known correlates of AD and psychiatric conditions and might be used as biomarkers to discriminate SCD individuals of different etiologies. The aim of the COSCODE study is to identify metacognition, connectivity, behavioral, and biomarker profiles associated with different etiologies of SCD. Here we present its rationale and study design.

  • Alzheimer's disease biomarkers
  • Connectivity
  • Metacognition
  • Subjective cognitive decline
Citation (ISO format)
RIBALDI, Federica et al. Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design. In: Alzheimer’s Research and Therapy, 2021, vol. 13, n° 1, p. 105. doi: 10.1186/s13195-021-00846-z
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Article (Published version)
ISSN of the journal1758-9193

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