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Title

Orbitofrontal-Striatal Structural Alterations Linked to Negative Symptoms at Different Stages of the Schizophrenia Spectrum

Authors
Kirschner, Matthias
Schmidt, André
Hodzic-Santor, Benazir
Burrer, Achim
Manoliu, Andrei
Zeighami, Yashar
Yau, Yvonne
Abbasi, Nooshin
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Published in Schizophrenia bulletin. 2021, vol. 47, no. 3, p. 849-863
Abstract Negative symptoms such as anhedonia and apathy are among the most debilitating manifestations of schizophrenia (SZ). Imaging studies have linked these symptoms to morphometric abnormalities in 2 brain regions implicated in reward and motivation: the orbitofrontal cortex (OFC) and striatum. Higher negative symptoms are generally associated with reduced OFC thickness, while higher apathy specifically maps to reduced striatal volume. However, it remains unclear whether these tissue losses are a consequence of chronic illness and its treatment or an underlying phenotypic trait. Here, we use multicentre magnetic resonance imaging data to investigate orbitofrontal-striatal abnormalities across the SZ spectrum from healthy populations with high schizotypy to unmedicated and medicated first-episode psychosis (FEP), and patients with chronic SZ. Putamen, caudate, accumbens volume, and OFC thickness were estimated from T1-weighted images acquired in all 3 diagnostic groups and controls from 4 sites (n = 337). Results were first established in 1 discovery dataset and replicated in 3 independent samples. There was a negative correlation between apathy and putamen/accumbens volume only in healthy individuals with schizotypy; however, medicated patients exhibited larger putamen volume, which appears to be a consequence of antipsychotic medications. The negative association between reduced OFC thickness and total negative symptoms also appeared to vary along the SZ spectrum, being significant only in FEP patients. In schizotypy, there was increased OFC thickness relative to controls. Our findings suggest that negative symptoms are associated with a temporal continuum of orbitofrontal-striatal abnormalities that may predate the occurrence of SZ. Thicker OFC in schizotypy may represent either compensatory or pathological mechanisms prior to the disease onset.
Keywords ApathyCortical thicknessFirst-episode psychosisNegative symptomsOrbitofrontal cortexSchizophrenia spectrumSchizotypyStriatumStructural MRI
Identifiers
PMID: 33257954
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Appendix (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: https://academic.oup.com/schizophreniabulletin/article/47/3/849/6012978
Structures
Research group Psychopathologie clinique et expérimentale (987)
Projects
Swiss National Science Foundation: P2SKP3_178175
Swiss National Science Foundation: 105314_140351
Swiss National Science Foundation: 10001CL_169783
Citation
(ISO format)
KIRSCHNER, Matthias et al. Orbitofrontal-Striatal Structural Alterations Linked to Negative Symptoms at Different Stages of the Schizophrenia Spectrum. In: Schizophrenia Bulletin, 2021, vol. 47, n° 3, p. 849-863. doi: 10.1093/schbul/sbaa169 https://archive-ouverte.unige.ch/unige:153676

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Deposited on : 2021-08-03

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