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Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration in Hydra

Published in Cold Spring Harbor perspectives in biology. 2021, no. a040725, p. 1-18
Abstract Here we discuss the developmental and homeostatic conditions necessary for Hydra regeneration. Hydra is characterized by populations of adult stem cells paused in the G2 phase of the cell cycle, ready to respond to injury signals. The body column can be compared to a blastema-like structure, populated with multifunctional epithelial stem cells that show low sensitivity to proapoptotic signals, and high inducibility of autophagy that promotes resistance to stress and starvation. Intact Hydra polyps also exhibit a dynamic patterning along the oral-aboral axis under the control of homeostatic organizers whose activity results from regulatory loops between activators and inhibitors. As in bilaterians, injury triggers the immediate production of reactive oxygen species (ROS) signals that promote wound healing and contribute to the reactivation of developmental programs via cell death and the de novo formation of new organizing centers from somatic tissues. In aging Hydra, regeneration is rapidly lost as homeostatic conditions are no longer pro-regenerative.
Keywords Hydra model systemWhole-body regenerationEpithelial stem cellsAutophagyReactive oxygen species (ROS) signalsDevelopmental organizerSp5 inhibition of Wnt/beta-catenin signalingBMP signaling
PMID: 34230037
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Research group Groupe Galliot
Swiss National Science Foundation: 31003_169930, 310030_ 189122
Autre: iGe3 fellowship
(ISO format)
VOGG, Matthias et al. Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration in Hydra. In: Cold Spring Harbor Perspectives in Biology, 2021, n° a040725, p. 1-18. doi: 10.1101/cshperspect.a040725 https://archive-ouverte.unige.ch/unige:153435

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Deposited on : 2021-07-27

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