en
Scientific article
Open access
English

Updated assessment of risks and benefits of dolutegravir versus efavirenz in new antiretroviral treatment initiators in sub-Saharan Africa: modelling to inform treatment guidelines

Published inThe Lancet HIV, vol. 7, no. 3, p. e193-e200
Publication date2020
Abstract

The integrase inhibitor dolutegravir is being considered in several countries in sub-Saharan Africa instead of efavirenz for people initiating antiretroviral therapy (ART) because of superior tolerability and a lower risk of resistance emergence. WHO requested updated modelling results for its 2019 Antiretroviral Guidelines update, which was restricted to the choice of dolutegravir or efavirenz in new ART initiators. In response to this request, we modelled the risks and benefits of alternative policies for initial first-line ART regimens.

Keywords
  • Adolescent
  • Adult
  • Africa South of the Sahara
  • Alkynes
  • Anti-HIV Agents/administration & dosage
  • Anti-HIV Agents/economics
  • Benzoxazines/administration & dosage
  • Benzoxazines/economics
  • Cost-Benefit Analysis
  • Cyclopropanes
  • Female
  • HIV Infections/drug therapy
  • HIV Infections/economics
  • HIV Infections/transmission
  • Heterocyclic Compounds, 3-Ring/administration & dosage
  • Heterocyclic Compounds, 3-Ring/economics
  • Humans
  • Infectious Disease Transmission, Vertical/prevention & control
  • Male
  • Middle Aged
  • Oxazines
  • Piperazines
  • Practice Guidelines as Topic
  • Pregnancy
  • Pregnancy Complications/drug therapy
  • Pregnancy Complications/virology
  • Pyridones
  • Randomized Controlled Trials as Topic
  • Young Adult
Research group
Funding
  • Autre - Bill & Melinda Gates Foundation
Citation (ISO format)
PHILLIPS, Andrew N et al. Updated assessment of risks and benefits of dolutegravir versus efavirenz in new antiretroviral treatment initiators in sub-Saharan Africa: modelling to inform treatment guidelines. In: The Lancet HIV, 2020, vol. 7, n° 3, p. e193–e200. doi: 10.1016/S2352-3018(19)30400-X
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal2352-3018
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54downloads

Technical informations

Creation10/30/2020 8:11:00 PM
First validation10/30/2020 8:11:00 PM
Update time03/16/2023 12:55:32 AM
Status update03/16/2023 12:55:31 AM
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