Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria

Diakité, Seidina A. S.; Ndour, Papa Alioune; Brousse, Valentine; Gay, Frederick; Roussel, Camille; Biligui, Sylvestre; Dussiot, Michaël; Prendki, Virginie; Lopera-Mesa, Tatiana M.; Traoré, Karim; Konaté, Drissa; Doumbia, Saibou; Cros, Jérôme; Dokmak, Safi; Fairhurst, Rick M.; Diakité, Mahamadou; Buffet, Pierre A.

doi:10.1186/s12936-016-1522-0

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Title		Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria
Authors		Diakité, Seidina A. S. Ndour, Papa Alioune Brousse, Valentine Gay, Frederick Roussel, Camille Biligui, Sylvestre Dussiot, Michaël Prendki, Virginie Lopera-Mesa, Tatiana M. Traoré, Karim Konaté, Drissa Doumbia, Saibou Cros, Jérôme Dokmak, Safi Fairhurst, Rick M. Diakité, Mahamadou Buffet, Pierre A. show all authors [1 - 17]
Published in		Malaria Journal. 2016, vol. 15, no. 1, p. 482
Abstract		Sickle-cell trait (HbAS) reduces falciparum malaria risk and suppresses parasitaemia. Although several candidate mechanisms have been proposed, their epidemiological, clinical and experimental correlates have not been adequately explained. To explore the basis for generally lower parasitaemias and delayed malaria episodes in children with HbAS, it is hypothesized here that their spleen-dependent removal of ring-infected red blood cells (RBCs) is more efficient than in children with normal haemoglobin A (HbAA).
Keywords		Malaria — Plasmodium falciparum — Red blood cell — Retention — Sickle-cell trait — Spleen
Identifiers		DOI: 10.1186/s12936-016-1522-0 PMID: 27655345
Full text		Article (Published version) (1.5 MB) - Free access Other version: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-016-1522-0
Research group		Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
Citation (ISO format)		DIAKITÉ, Seidina A. S. et al. Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria. In: Malaria Journal, 2016, vol. 15, n° 1, p. 482. doi: 10.1186/s12936-016-1522-0 https://archive-ouverte.unige.ch/unige:153235