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Title

Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria

Authors
Diakité, Seidina A. S.
Ndour, Papa Alioune
Brousse, Valentine
Gay, Frederick
Roussel, Camille
Biligui, Sylvestre
Dussiot, Michaël
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Published in Malaria Journal. 2016, vol. 15, no. 1, p. 482
Abstract Sickle-cell trait (HbAS) reduces falciparum malaria risk and suppresses parasitaemia. Although several candidate mechanisms have been proposed, their epidemiological, clinical and experimental correlates have not been adequately explained. To explore the basis for generally lower parasitaemias and delayed malaria episodes in children with HbAS, it is hypothesized here that their spleen-dependent removal of ring-infected red blood cells (RBCs) is more efficient than in children with normal haemoglobin A (HbAA).
Keywords MalariaPlasmodium falciparumRed blood cellRetentionSickle-cell traitSpleen
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PMID: 27655345
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Research group Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
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DIAKITÉ, Seidina A. S. et al. Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria. In: Malaria Journal, 2016, vol. 15, n° 1, p. 482. doi: 10.1186/s12936-016-1522-0 https://archive-ouverte.unige.ch/unige:153235

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Deposited on : 2021-07-21

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