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Scientific article
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English

Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria

Published inMalaria Journal, vol. 15, no. 1, 482
Publication date2016
Abstract

Sickle-cell trait (HbAS) reduces falciparum malaria risk and suppresses parasitaemia. Although several candidate mechanisms have been proposed, their epidemiological, clinical and experimental correlates have not been adequately explained. To explore the basis for generally lower parasitaemias and delayed malaria episodes in children with HbAS, it is hypothesized here that their spleen-dependent removal of ring-infected red blood cells (RBCs) is more efficient than in children with normal haemoglobin A (HbAA).

Keywords
  • Malaria
  • Plasmodium falciparum
  • Red blood cell
  • Retention
  • Sickle-cell trait
  • Spleen
Affiliation Not a UNIGE publication
Citation (ISO format)
DIAKITÉ, Seidina A. S. et al. Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria. In: Malaria Journal, 2016, vol. 15, n° 1, p. 482. doi: 10.1186/s12936-016-1522-0
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Article (Published version)
Identifiers
ISSN of the journal1475-2875
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