en
Scientific article
Open access
English

Digestive-tract sarcoidosis: French nationwide case-control study of 25 cases

Published inMedicine (Baltimore), vol. 95, no. 29, e4279
Publication date2016
Abstract

Digestive tract sarcoidosis (DTS) is rare and case-series are lacking. In this retrospective case-control study, we aimed to compare the characteristics, outcome, and treatment of patients with DTS, nondigestive tract sarcoidosis (NDTS), and Crohn disease.We included cases of confirmed sarcoidosis, symptomatic digestive tract involvement, and noncaseating granuloma in any digestive tract. Each case was compared with 2 controls with sarcoidoisis without digestive tract involvement and 4 with Crohn disease.We compared 25 cases of DTS to 50 controls with NDTS and 100 controls with Crohn disease. The major digestive clinical features were abdominal pain (56%), weight loss (52%), nausea/vomiting (48%), diarrhea (32%), and digestive bleeding (28%). On endoscopy of DTS, macroscopic lesions were observed in the esophagus (9%), stomach (78%), duodenum (9%), colon, (25%) and rectum (19%). As compared with NDTS, DTS was associated with weight loss (odds ratio [OR] 5.8; 95% confidence interval [CI] 1.44-23.3) and the absence of thoracic adenopathy (OR 5.0; 95% CI 1.03-25). As compared with Crohn disease, DTS was associated with Afro-Caribbean origin (OR 27; 95% CI 3.6-204) and the absence of ileum or colon macroscopic lesions (OR 62.5; 95% CI 10.3-500). On the last follow-up, patients with DTS showed no need for surgery (versus 31% for patients with Crohn disease; P = 0.0013), and clinical digestive remission was frequent (76% vs. 35% for patients with Crohn disease; P = 0.0002).The differential diagnosis with Crohn disease could be an issue with DTS. Nevertheless, the 2 diseases often have different clinical presentation and outcome.

Keywords
  • Adult
  • Aged
  • Case-Control Studies
  • Cohort Studies
  • Crohn Disease/diagnosis
  • Crohn Disease/epidemiology
  • Crohn Disease/therapy
  • Cross-Sectional Studies
  • Diagnosis, Differential
  • Digestive System Diseases/diagnosis
  • Digestive System Diseases/epidemiology
  • Digestive System Diseases/therapy
  • Endoscopy, Digestive System
  • Female
  • France
  • Humans
  • Male
  • Middle Aged
  • Remission, Spontaneous
  • Sarcoidosis/diagnosis
  • Sarcoidosis/epidemiology
  • Sarcoidosis/therapy
  • Young Adult
Citation (ISO format)
GHRENASSIA, Etienne et al. Digestive-tract sarcoidosis: French nationwide case-control study of 25 cases. In: Medicine (Baltimore), 2016, vol. 95, n° 29, p. e4279. doi: 10.1097/MD.0000000000004279
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal0025-7974
128views
50downloads

Technical informations

Creation10/19/2020 7:31:00 PM
First validation10/19/2020 7:31:00 PM
Update time03/16/2023 12:55:05 AM
Status update03/16/2023 12:55:04 AM
Last indexation02/12/2024 1:28:16 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack