An International Prospective Cohort Study To Validate 2 Prediction Rules for Infections Caused by Third-generation Cephalosporin-resistant Enterobacterales

Deelen, J W Timotëus; Rottier, Wouter C; Giron Ortega, José A; Rodriguez-Baño, Jesús; Harbarth, Stéphan Juergen; Tacconelli, Evelina; Jacobsson, Gunnar; Zahar, Jean-Ralph; van Werkhoven, Cornelis H; Bonten, Marc J M; SBL-PREDICT Study Team

doi:10.1093/cid/ciaa950

Scientific article

Open access

English

An International Prospective Cohort Study To Validate 2 Prediction Rules for Infections Caused by Third-generation Cephalosporin-resistant Enterobacterales

ContributorsDeelen, J W Timotëus; Rottier, Wouter C; Giron Ortega, José A; Rodriguez-Baño, Jesús; Harbarth, Stéphan Juergen

; Tacconelli, Evelina; Jacobsson, Gunnar; Zahar, Jean-Ralph; van Werkhoven, Cornelis H; Bonten, Marc J M; SBL-PREDICT Study Team

Published inClinical Infectious Diseases, ciaa950

Publication date2020

Abstract

The possibility of bloodstream infections caused by 3rd-generation cephalosporin-resistant Enterobacterales (3GC-R-BSI) leads to a trade-off between empiric inappropriate treatment (IAT) and unnecessary carbapenem use (UCU). Accurately predicting 3GC-R-BSI could reduce IAT and UCU. We externally validate two previously derived prediction rules for community-onset (CO) and hospital-onset (HO) suspected bloodstream infections.

Keywords

Antibiotic resistance
Antibiotics
Bacteraemia
Bloodstream infection
ESBL
Carbapenems

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Epidémiologie et contrôle de la résistance aux antibiotiques (866)

Citation (ISO format)

DEELEN, J W Timotëus et al. An International Prospective Cohort Study To Validate 2 Prediction Rules for Infections Caused by Third-generation Cephalosporin-resistant Enterobacterales. In: Clinical Infectious Diseases, 2020, p. ciaa950. doi: 10.1093/cid/ciaa950