Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension

Oddo, M; Levine, J M; Frangos, S; Carrera, Emmanuel; Maloney-Wilensky, E; Pascual, J L; Kofke, W A; Mayer, S A; LeRoux, P D

doi:10.1136/jnnp.2008.156596

Scientific article

English

Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension

ContributorsOddo, M; Levine, J M; Frangos, S; Carrera, Emmanuel; Maloney-Wilensky, E; Pascual, J L; Kofke, W A; Mayer, S A; LeRoux, P D

Published inJournal of Neurology, Neurosurgery, and Psychiatry, vol. 80, no. 8, p. 916-920

Publication date2009

Abstract

The impact of osmotic therapies on brain oxygen has not been extensively studied in humans. We examined the effects on brain tissue oxygen tension (PbtO(2)) of mannitol and hypertonic saline (HTS) in patients with severe traumatic brain injury (TBI) and refractory intracranial hypertension.

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Citation (ISO format)

ODDO, M et al. Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension. In: Journal of Neurology, Neurosurgery, and Psychiatry, 2009, vol. 80, n° 8, p. 916–920. doi: 10.1136/jnnp.2008.156596

Article (Published version)

Identifiers

PID : unige:152851
DOI : 10.1136/jnnp.2008.156596
PMID : 19293171

Additional URL for this publicationhttps://jnnp.bmj.com/lookup/doi/10.1136/jnnp.2008.156596

Journal ISSN0022-3050

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Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension

The impact of osmotic therapies on brain oxygen has not been extensively studied in humans. We examined the effects on brain tissue oxygen tension (PbtO(2)) of mannitol and hypertonic saline (HTS) in patients with severe traumatic brain injury (TBI) and refractory intracranial hypertension.

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