en
Scientific article
Letter
English

Asymmetric alkylations of a sultam-derived glycinate equivalent: practical preparation of enantiomerically pure α-amino acids

Published inTetrahedron Letters, vol. 30, no. 44, p. 6009-6010
Publication date1989
Abstract

Deprotonation/alkylation of sultam-derived N-[bis(methyl)thiomethylene]glycinate equivalent 3 gave crystalline products 5 which on mild hydrolysis furnished α-amino acids 7 (~100% e.e.) in high overall yield. Deprotonation/alkylation/mild hydrolysis 3→5→7 gave α-amino acids 7 (100% e.e) in high overall yield.

Citation (ISO format)
VON OPPOLZER, Wolfgang, MORETTI, Robert, THOMI, Silvia Béatrice. Asymmetric alkylations of a sultam-derived glycinate equivalent: practical preparation of enantiomerically pure α-amino acids. In: Tetrahedron Letters, 1989, vol. 30, n° 44, p. 6009–6010. doi: 10.1016/S0040-4039(01)93840-7
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0040-4039
113views
0downloads

Technical informations

Creation06/29/2021 11:28:00 AM
First validation06/29/2021 11:28:00 AM
Update time03/16/2023 12:50:13 AM
Status update03/16/2023 12:50:12 AM
Last indexation01/17/2024 1:36:22 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack