en
Doctoral thesis
Open access
English

Evolution of sub/supercritical fluid chromatography – mass spectrometry for the analysis of highly polar compounds and biological matrices

Defense date2021-06-09
Abstract

The scope of this thesis has focused on the investigation of the performance and robustness of UHPSFC-MS in routine laboratories. Furthermore, the analysis of highly polar compounds was tested using UHPSFC, to verify the potential attractiveness of this technique not only as an alternative to RPLC but also to HILIC analysis, in which strongly polar and hydrophilic substances are analyzed. To this purpose, UHPSFC has been applied in different fields, such as untargeted metabolomics employing different biological matrices and peptide analysis. Finally, some fundamental aspects of UHPSFC have been also the subject of work, in an attempt to complement the knowledge on the mechanisms controlling this technique.

eng
Keywords
  • Supercritical fluid chromatography
  • Unified chromatography
  • Mass spectrometry
  • Metabolomics
  • Peptide analysis
  • Antidoping analysis
Citation (ISO format)
LOSACCO, Gioacchino Luca. Evolution of sub/supercritical fluid chromatography – mass spectrometry for the analysis of highly polar compounds and biological matrices. 2021. doi: 10.13097/archive-ouverte/unige:152708
Main files (1)
Thesis
accessLevelPublic
Identifiers
395views
243downloads

Technical informations

Creation06/28/2021 7:40:00 AM
First validation06/28/2021 7:40:00 AM
Update time03/07/2024 11:18:54 AM
Status update03/07/2024 11:18:54 AM
Last indexation03/07/2024 11:18:56 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack