Scientific article
Open access

Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update

Published inNutrients, vol. 12, no. 7
Publication date2020

Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which present with symptoms of variable severity, affecting the gastrointestinal tract in response to specific dietary antigens. The diagnosis of non-IgE-GI-FA is made clinically, and relies on a constellation of typical symptoms that improve upon removal of the culprit food. When possible, food reintroduction should be attempted, with the documentation of symptoms relapse to establish a conclusive diagnosis. Management includes dietary avoidance, nutritional counselling, and supportive measures in the case of accidental exposure. The prognosis is generally favorable, with the majority of cases resolved before school age. Serial follow-up to establish whether the acquisition of tolerance has occurred is therefore essential in order to avoid unnecessary food restriction and potential consequent nutritional deficiencies. The purpose of this review is to delineate the distinctive clinical features of non-IgE-mediated food allergies presenting with gastrointestinal symptomatology, to summarize our current understanding of the pathogenesis driving these diseases, to discuss recent findings, and to address currents gaps in the knowledge, to guide future management opportunities.

  • Food allergy
  • Non-IgE-mediated
  • Nutrition
  • Pediatrics
  • FPE
  • Gastrointestinal reactions
Citation (ISO format)
LABROSSE, Roxane, GRAHAM, François, CAUBET, Jean-Christoph Roger J-P. Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update. In: Nutrients, 2020, vol. 12, n° 7. doi: 10.3390/nu12072086
Main files (1)
Article (Published version)
ISSN of the journal2072-6643

Technical informations

Creation10/21/2020 4:00:00 PM
First validation10/21/2020 4:00:00 PM
Update time03/16/2023 12:49:09 AM
Status update03/16/2023 12:49:08 AM
Last indexation02/12/2024 12:07:16 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack