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Scientific article
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English

The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

Published inClinical Kidney Journal, vol. 13, no. 3, p. 371-379
Publication date2020
Abstract

Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature.

Keywords
  • Development
  • Kidney disease
  • Obstructive uropathy
  • Prediction
  • Prenatal biomarkers
Citation (ISO format)
BUFFIN-MEYER, Bénédicte et al. The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design. In: Clinical Kidney Journal, 2020, vol. 13, n° 3, p. 371–379. doi: 10.1093/ckj/sfz107
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Article (Published version)
Identifiers
ISSN of the journal2048-8505
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Technical informations

Creation10/21/2020 5:21:00 PM
First validation10/21/2020 5:21:00 PM
Update time03/16/2023 12:49:05 AM
Status update03/16/2023 12:49:03 AM
Last indexation02/12/2024 1:27:53 PM
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