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Dysmaturation Observed as Altered Hippocampal Functional Connectivity at Rest Is Associated With the Emergence of Positive Psychotic Symptoms in Patients With 22q11 Deletion Syndrome

Published inBiological Psychiatry, vol. 90, no. 1, p. 58-68
Publication date2021
Abstract

Hippocampal alterations are among the most replicated neuroimaging findings across the psychosis spectrum. Moreover, there is strong translational evidence that preserving the maturation of hippocampal networks in mice models prevents the progression of cognitive deficits. However, the developmental trajectory of hippocampal functional connectivity (HFC) and its contribution to psychosis is not well characterized in the human population. 22q11 deletion syndrome (22q11DS) offers a unique model for characterizing early neural correlates of schizophrenia.

Keywords
  • Circuit dysmaturation
  • Critical periods
  • Hippocampus
  • Psychosis
  • Resting state functional connectivity
  • 22q11 deletion syndrome
Citation (ISO format)
DELAVARI, Farnaz et al. Dysmaturation Observed as Altered Hippocampal Functional Connectivity at Rest Is Associated With the Emergence of Positive Psychotic Symptoms in Patients With 22q11 Deletion Syndrome. In: Biological Psychiatry, 2021, vol. 90, n° 1, p. 58–68. doi: 10.1016/j.biopsych.2020.12.033
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ISSN of the journal0006-3223
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Creation04/22/2021 1:45:00 PM
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