Dysmaturation Observed as Altered Hippocampal Functional Connectivity at Rest Is Associated With the Emergence of Positive Psychotic Symptoms in Patients With 22q11 Deletion Syndrome

Delavari, Farnaz; Sandini, Corrado; Zoeller, Daniela; Mancini, Valentina; Bortolin, Karin; Schneider, Maude; Van De Ville, Dimitri; Eliez, Stéphan

doi:10.1016/j.biopsych.2020.12.033

Scientific article

English

Dysmaturation Observed as Altered Hippocampal Functional Connectivity at Rest Is Associated With the Emergence of Positive Psychotic Symptoms in Patients With 22q11 Deletion Syndrome

ContributorsDelavari, Farnaz; Sandini, Corrado

; Zoeller, Daniela; Mancini, Valentina

; Bortolin, Karin; Schneider, Maude; Van De Ville, Dimitri

; Eliez, Stéphan

Published inBiological Psychiatry, vol. 90, no. 1, p. 58-68

Publication date2021

Abstract

Hippocampal alterations are among the most replicated neuroimaging findings across the psychosis spectrum. Moreover, there is strong translational evidence that preserving the maturation of hippocampal networks in mice models prevents the progression of cognitive deficits. However, the developmental trajectory of hippocampal functional connectivity (HFC) and its contribution to psychosis is not well characterized in the human population. 22q11 deletion syndrome (22q11DS) offers a unique model for characterizing early neural correlates of schizophrenia.

Keywords

Circuit dysmaturation
Critical periods
Hippocampus
Psychosis
Resting state functional connectivity
22q11 deletion syndrome

Affiliation entities

Research groups

Funding

Swiss National Science Foundation - Swiss VCFS Cohort: a 10-year longitudinal investigation from genes to brain to cognition for understanding psychosis proneness in 22q11.2 deletion [324730_144260]
Swiss National Science Foundation - NCCR SYNAPSY: The synaptic bases of mental diseases (phase II)
Swiss National Science Foundation - 324730_121996M; 324730_144260; 51NF40-158776
Swiss National Science Foundation - Towards an embodied and ecological understanding of social impairments in neurodevelopmental disorders [PZ00P1_174206]

Citation (ISO format)

DELAVARI, Farnaz et al. Dysmaturation Observed as Altered Hippocampal Functional Connectivity at Rest Is Associated With the Emergence of Positive Psychotic Symptoms in Patients With 22q11 Deletion Syndrome. In: Biological Psychiatry, 2021, vol. 90, n° 1, p. 58–68. doi: 10.1016/j.biopsych.2020.12.033