en
Scientific article
Review
English

The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts' Consensus

Published inAutoimmunity Reviews, vol. 20, no. 2, 102738
Publication date2021
Abstract

Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure. Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. In this work, the growing body of evidence is summarized regarding the predictive factors for drug response in patients with AIDs, applying the precision medicine principles to provide high-quality evidence for therapeutic opportunities in improving the management of these patients.

Keywords
  • Autoimmune Diseases/therapy
  • Consensus
  • Humans
  • Lupus Erythematosus, Systemic
  • Precision Medicine
  • Sjogren's Syndrome
Citation (ISO format)
GIACOMELLI, Roberto et al. The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts” Consensus. In: Autoimmunity Reviews, 2021, vol. 20, n° 2, p. 102738. doi: 10.1016/j.autrev.2020.102738
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1568-9972
171views
0downloads

Technical informations

Creation03/23/2021 2:53:00 PM
First validation03/23/2021 2:53:00 PM
Update time03/16/2023 12:48:21 AM
Status update03/16/2023 12:48:16 AM
Last indexation05/06/2024 7:46:09 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack