Anti-Apolipoprotein A-1 IgG Influences Neutrophil Extracellular Trap Content at Distinct Regions of Human Carotid Plaques

da Silva, Rafaela; Baptista, Daniela; Roth, Aline; Miteva, Kapka Todorova; Burger, Fabienne; Vuilleumier, Nicolas; Carbone, Federico; Montecucco, Fabrizio; Mach, François; Brandt, Karim

doi:10.3390/ijms21207721

Scientific article

Open access

English

Anti-Apolipoprotein A-1 IgG Influences Neutrophil Extracellular Trap Content at Distinct Regions of Human Carotid Plaques

Contributorsda Silva, Rafaela; Baptista, Daniela; Roth, Aline; Miteva, Kapka Todorova

; Burger, Fabienne; Vuilleumier, Nicolas; Carbone, Federico; Montecucco, Fabrizio; Mach, François; Brandt, Karim

Published inInternational Journal of Molecular Sciences, vol. 21, no. 20, 7721

Publication date2020

Abstract

Neutrophils accumulate in atherosclerotic plaques. Neutrophil extracellular traps (NET) were recently identified in experimental atherosclerosis and in complex human lesions. However, not much is known about the NET marker citrullinated histone-3 (H3Cit) expression and functionality in human carotid plaques. Moreover, the association between the proatherosclerotic autoantibody anti-apolipoprotein A-1 (anti-ApoA-1 IgG) and NET has never been investigated.

Keywords

Atherosclerosis
Vulnerable plaques
Anti-apoA-1 IgG
Neutrophil extracellular traps

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Funding

Swiss National Science Foundation - Role of B cell subsets in atherosclerotic plaque vulnerability and peripheral tissue ischemic injury [310030_152912]

Citation (ISO format)

DA SILVA, Rafaela et al. Anti-Apolipoprotein A-1 IgG Influences Neutrophil Extracellular Trap Content at Distinct Regions of Human Carotid Plaques. In: International Journal of Molecular Sciences, 2020, vol. 21, n° 20, p. 7721. doi: 10.3390/ijms21207721