en
Scientific article
Review
Open access
English

Multiple Endocrine Neoplasia Type 1 (MEN1) and the Pancreas - Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement

Published inNeuroendocrinology, vol. 111, no. 7, p. 609-630
Publication date2020
Abstract

The better understanding of the biological behavior of MEN1 organ manifestations and the in-crease in clinical experience warrant a revision of previously published guidelines. DP-NENs are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to re-evaluate recommendations for their diagnosis and treatment. Especially over the last two years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs. It was the aim of the international consortium of experts in endocrinology, genetics, radiology, surgery, gastroenterology and oncology to systematically review the literature and to present a consensus statement based on the highest levels of evidence. Reviewing the literature published over the past decade, the focus was on the diagnosis of F- and NF-DP-NENs within the MEN1 syn-drome in an effort to further standardize and improve treatment and follow-up, as well as to es-tablish a "logbook" for the diagnosis and treatment of DP-NENs. This shall help further reduce complications and improve long-term treatment results in these rare tumors. The following international consensus statement builds upon the previously published guide-lines of 2001 and 2012 and attempts to supplement the recommendations issued by various na-tional and international societies.

Keywords
  • Consensus statement
  • Diagnosis
  • Multiple endocrine neoplasia type 1
  • Neuroendocrine pancreatic tumors
  • Treatment
Citation (ISO format)
NIEDERLE, Bruno et al. Multiple Endocrine Neoplasia Type 1 (MEN1) and the Pancreas - Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement. In: Neuroendocrinology, 2020, vol. 111, n° 7, p. 609–630. doi: 10.1159/000511791
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal0028-3835
138views
51downloads

Technical informations

Creation10/20/2020 11:34:00 AM
First validation10/20/2020 11:34:00 AM
Update time03/16/2023 12:47:34 AM
Status update03/16/2023 12:47:32 AM
Last indexation02/12/2024 1:27:45 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack