Spontaneous hyperventilation and brain tissue hypoxia in patients with severe brain injury

Carrera, Emmanuel; Schmidt, J Michael; Fernandez, Luis; Kurtz, Pedro; Merkow, Maxwell; Stuart, Morgan; Lee, Kiwon; Claassen, Jan; Sander Connolly, E; Mayer, Stephan A; Badjatia, Neeraj

doi:10.1136/jnnp.2009.174425

Scientific article

English

Spontaneous hyperventilation and brain tissue hypoxia in patients with severe brain injury

ContributorsCarrera, Emmanuel; Schmidt, J Michael; Fernandez, Luis; Kurtz, Pedro; Merkow, Maxwell; Stuart, Morgan; Lee, Kiwon; Claassen, Jan; Sander Connolly, E; Mayer, Stephan A; Badjatia, Neeraj

Published inJournal of Neurology, Neurosurgery, and Psychiatry, vol. 81, no. 7, p. 793-797

Publication date2010

Abstract

Hyperventilation has been shown to be associated with cerebral vasoconstriction and increased risk of infarction. Our aim was to determine whether spontaneous reduction in end-tidal CO(2) (EtCO(2)) was associated with an increased in brain tissue hypoxia (BTH).

Keywords

Adult
Aged
Blood Gas Analysis
Brain Injuries/complications
Carbon Dioxide/blood
Coma/blood/etiology
Female
Glasgow Coma Scale
Heart Rate/physiology
Humans
Hyperventilation/etiology
Hypoxia, Brain/etiology
Intracranial Pressure/physiology
Male
Middle Aged
Prospective Studies
Respiration, Artificial
Respiratory Mechanics/physiology
Tidal Volume/physiology

UNIGE affiliation entities

Not a UNIGE publication

Funding

Swiss National Science Foundation - PBLAB-119620

Citation (ISO format)

CARRERA, Emmanuel et al. Spontaneous hyperventilation and brain tissue hypoxia in patients with severe brain injury. In: Journal of Neurology, Neurosurgery, and Psychiatry, 2010, vol. 81, n° 7, p. 793–797. doi: 10.1136/jnnp.2009.174425

Article (Published version)

Identifiers

PID : unige:152475
DOI : 10.1136/jnnp.2009.174425
PMID : 19965840

Additional URL for this publicationhttps://jnnp.bmj.com/content/81/7/793.long

Journal ISSN0022-3050

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Spontaneous hyperventilation and brain tissue hypoxia in patients with severe brain injury

Hyperventilation has been shown to be associated with cerebral vasoconstriction and increased risk of infarction. Our aim was to determine whether spontaneous reduction in end-tidal CO(2) (EtCO(2)) was associated with an increased in brain tissue hypoxia (BTH).

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