Scientific article
Open access

Lymphatic connexins and pannexins in health and disease

Published inInternational Journal of Molecular Sciences, vol. 22, no. 11, 5734
Publication date2021

This review highlights current knowledge on the expression and function of connexins and pannexins, transmembrane channel proteins that play an important role in intercellular communication, in both the developing and mature lymphatic vasculature. A particular focus is given to the involvement of these proteins in functions of the healthy lymphatic system. We describe their influence on the maintenance of extracellular fluid homeostasis, immune cell trafficking to draining lymph nodes and dietary nutrient absorption by intestinal villi. Moreover, new insights into connexin mutations in primary and secondary lymphedema as well as on the implication of lymphatic connexins and pannexins in acquired cardiovascular diseases are discussed, allowing for a better understanding of the role of these proteins in pathologies linked to dysfunctions in the lymphatic system.

Citation (ISO format)
EHRLICH, Avigail et al. Lymphatic connexins and pannexins in health and disease. In: International Journal of Molecular Sciences, 2021, vol. 22, n° 11, p. 5734. doi: 10.3390/ijms22115734
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Article (Published version)
ISSN of the journal1661-6596

Technical informations

Creation06/04/2021 9:50:00 AM
First validation06/04/2021 9:50:00 AM
Update time03/16/2023 12:44:50 AM
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