Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging

Scheffler, Max; Salomir, Rares; Maturana, Enrique; Montandon Zaidi, Marie-Louise; Kovari, Eniko Veronika; Haller, Sven

doi:10.1007/s00234-021-02717-8

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Title		Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging
Authors		Scheffler, Max Salomir, Rares Maturana, Enrique Montandon Zaidi, Marie-Louise Kovari, Eniko Veronika Haller, Sven
Published in		Neuroradiology. 2021
Abstract		Cortical microinfarcts (CMI) are increasingly recognized in the neurological community as a biomarker related to cognitive impairment and dementia. If their radiological depiction has been largely described in experimental settings using ultra-high-field magnetic resonance imaging (MRI), less is known about their visibility on routinely used 3-T MRI. In this radiologic-pathologic correlation study, using 3-T post-mortem MRI, we searched for hippocampal CMI, in a double-blinded fashion, and found that only 4/36, or 11%, were clearly demonstrated on both radiological and histopathological exams.
Keywords		Cerebral microinfarcts — Hippocampus — Dementia — 3-T post-mortem MRI — Histopathology
Identifiers		DOI: 10.1007/s00234-021-02717-8 PMID: 33909116
Full text		Article (Published version) (608 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie
Research group		Neuroimagerie moléculaire en psychiatrie (983)
Project		FNS: 320030_159990/1
Citation (ISO format)		SCHEFFLER, Max et al. Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging. In: Neuroradiology, 2021. doi: 10.1007/s00234-021-02717-8 https://archive-ouverte.unige.ch/unige:152335