Scientific article
Letter
English

A concise Diastereospecific Synthesis of 3-Amino-2-hydroxy Acids

Published inTetrahedron Letters, vol. 34, no. 47, p. 7557-7560
Publication date1993
Abstract

L-Aspartic acid by N-tosylation, anhydride formation, reduction, α-hydroxylation, iodo esterification and alkylation followed by saponification and deprotection afforded a series of 4-alkyl-3-amino-2-hydroxybutyric acids having the 2S,3R configuration (de>95%).

Keywords
  • Aspartic acid
  • Diastereoselective hydroxylation
Funding
  • Swiss National Science Foundation - 20-32'166.91
Citation (ISO format)
JEFFORD, Charles, WANG, Jian Bo, LU, Zhi-Hui. A concise Diastereospecific Synthesis of 3-Amino-2-hydroxy Acids. In: Tetrahedron Letters, 1993, vol. 34, n° 47, p. 7557–7560. doi: 10.1016/S0040-4039(00)60398-2
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0040-4039
129views
0downloads

Technical informations

Creation02/06/2021 09:05:00
First validation02/06/2021 09:05:00
Update time16/03/2023 00:41:08
Status update16/03/2023 00:41:07
Last indexation10/06/2025 21:42:42
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack