UNIGE document Scientific Article
previous document  unige:151962  next document
add to browser collection
Title

Tolbutamide eye drops increase aqueous humor outflow and lower intraocular pressure: a proof of concept for glaucoma treatment

Authors
Sorgente, Nino
Published in Journal of Ophthalmology and Research. 2021, vol. 4, no. 2, p. 114-127
Abstract Background: Glaucoma refers to a heterogeneous group of diseases characterized by retinal cell degeneration and optic nerve atrophy leading to blindness. Even though about 40% of patients have normal intraocular pressure (IOP), current treatment. focuses on lowering IOP. With time, current drugs become less effective, which has motivated the search for novel drugs.The objective was to establish whether modulators of ATP-sensitive potassium channels influence IOP. Methods: The double-blind, 5-day short duration Proof-Of-Concept study was carried out at the Ophthalmology Clinic, University of Cologne, Germany. The only inclusion criteria were a diagnosis of glaucoma, ability to understand that they would be treated with an experimental drug, and readiness to sign a consent form. Results: In rabbits, 1 h after topical application of 80 µL of 0.5% tolazamide, tolbutamide, glibenclamide, and chlorpropamide suspended in phosphate buffered saline IOP de-creased, whereas 0.5% diazoxide increased IOP. In Cynomolgus monkeys tolbutamide decreased IOP. In 9 glaucoma patients treated for 5 days with one drop of a 0.5% tolbutamide solution twice daily, IOP was an average of 17% lowered. In one patient with ocular hypertension, tolbutamide lowered IOP by a 5-day average of 29% and increased aqueous humor outflow by 185%. No local adverse effects were observed. Conclusions: The data presented show that blockers of the ATP-sensitive potassium channels lower IOP whereas diazoxide, an ATP-sensitive potassium channel opener, increases IOP suggesting that elevated IOP results from an ionic imbalance. The data suggest that sulfonylurea drugs are useful for the treatment of glaucoma.
Keywords GlaucomaOpen-angle glaucomaTolbutamideATP-sensitive potassium channelsATP-sensitive potassium channel openerATP-sensitive potassium channel blockerIntraocular pressureAqueous humor outflow
Identifiers
Full text
Structures
Research group Ophtalmologie expérimentale (925)
Citation
(ISO format)
THUMANN, Gabriele et al. Tolbutamide eye drops increase aqueous humor outflow and lower intraocular pressure: a proof of concept for glaucoma treatment. In: Journal of Ophthalmology and Research, 2021, vol. 4, n° 2, p. 114-127. doi: 10.26502/fjor.2644-00240031 https://archive-ouverte.unige.ch/unige:151962

42 hits

30 downloads

Update

Deposited on : 2021-05-28

Export document
Format :
Citation style :