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Title

Dietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males

Authors
Burnier, Michel
Maillard, Marc
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Published in Nephrology Dialysis Transplantation. 2021
Abstract Background The effects of sodium (Na+) intakes on renal handling of potassium (K+) are insufficiently studied. Methods We assessed the effect of Na+ on renal K+ handling in 16 healthy males assigned to three 7-day periods on low salt diet [LSD, 3 g sodium chloride (NaCl)/day], normal salt diet (NSD, 6 g NaCl/day) and high salt diet (HSD, 15 g NaCl/day), with constant K+ intake. Contributions of distal NaCl co-transporter and epithelial Na+ channel in the collecting system on K+ and Na+ handling were assessed at steady state by acute response to 100 mg oral hydrochlorothiazide and with addition of 10 mg of amiloride to hydrochlorothiazide, respectively. Results Diurnal blood pressure slightly increased from 119.30 ± 7.95 mmHg under LSD to 123.00 ± 7.50 mmHg (P = 0.02) under HSD, while estimated glomerular filtration rate increased from 133.20 ± 34.68 mL/min under LSD to 187.00 ± 49.10 under HSD (P = 0.005). The 24-h K+ excretion remained stable on all Na+ intakes (66.28 ± 19.12 mmol/24 h under LSD; 55.91 ± 21.17 mmol/24 h under NSD; and 66.81 ± 20.72 under HSD, P = 0.9). The hydrochlorothiazide-induced natriuresis was the highest under HSD (30.22 ± 12.53 mmol/h) and the lowest under LSD (15.38 ± 8.94 mmol/h, P = 0.02). Hydrochlorothiazide increased kaliuresis and amiloride decreased kaliuresis similarly on all three diets. Conclusions Neither spontaneous nor diuretic-induced K+ excretion was influenced by Na+ intake in healthy male subjects. However, the respective contribution of the distal convoluted tubule and the collecting duct to renal Na+ handling was dependent on dietary Na+ intake.
Identifiers
PMID: 33492394
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Research groups Laboratoire de physiologie et pathophysiologie des cellules rénales (29)
Groupe Pierre-Yves Martin (néphrologie) (30)
Insuffisance rénale chronique (941)
Hypertension artérielle (128)
Project FNS: 31003 A_175471/1
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PECHERE, Antoinette et al. Dietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males. In: Nephrology Dialysis Transplantation, 2021. doi: 10.1093/ndt/gfaa381 https://archive-ouverte.unige.ch/unige:151960

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Deposited on : 2021-05-28

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