An Enantiospecific Synthesis of β-Amino Acids

Jefford, Charles; Wang, Jian Bo

doi:10.1016/S0040-4039(00)77503-4

Scientific article

Letter

English

An Enantiospecific Synthesis of β-Amino Acids

ContributorsJefford, Charles; Wang, Jian Bo

Published inTetrahedron Letters, vol. 34, no. 7, p. 1111-1114

Publication date1993

Abstract

L-Aspartic acid by regioselective modification of the α-carboxylic acid group, namely N-tosylation, anhydride formation, reduction, iodo-esterification, alkylation, and deprotection afforded a series of γ-alkyl β-aminobutyric acids of the R configuration (ee>99%).

Keywords

Aspartic acid
N-camphanoyl ester
Enantiomeric purity

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Funding

Swiss National Science Foundation - 20-32166.91

Citation (ISO format)

JEFFORD, Charles, WANG, Jian Bo. An Enantiospecific Synthesis of β-Amino Acids. In: Tetrahedron Letters, 1993, vol. 34, n° 7, p. 1111–1114. doi: 10.1016/S0040-4039(00)77503-4

Article (Published version)

Identifiers

PID : unige:151890
DOI : 10.1016/S0040-4039(00)77503-4

Additional URL for this publicationhttps://linkinghub.elsevier.com/retrieve/pii/S0040403900775034

Journal ISSN0040-4039

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An Enantiospecific Synthesis of β-Amino Acids

L-Aspartic acid by regioselective modification of the α-carboxylic acid group, namely N-tosylation, anhydride formation, reduction, iodo-esterification, alkylation, and deprotection afforded a series of γ-alkyl β-aminobutyric acids of the R configuration (ee>99%).

Technical informations