en
Scientific article
Open access
English

Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans

Published inBlood, vol. 114, no. 24, p. 4998-5002
Publication date2009
Abstract

In humans, the kinetics of the appearance of memory B cells and plasma cells during primary immunization are not well defined. In this study, we assessed the primary B-cell response of rabies-antigen naive volunteers during a 3-dose course of rabies vaccine compared with the B-cell response to a booster dose of rabies vaccine given to previously immunized volunteers. After a single dose of vaccine, in the naive group plasma and memory B cells appeared later (peak at day 10) than in the primed group (peak at day 7) and were at lower frequency. The most rapid responses (day 4) were detected after a third immunization in the naive group. This is the first study to document the detailed kinetics of the plasma cell and memory B-cell responses to immunization in adult humans and to demonstrate differences in the responses that relate to the preexisting immune status of the persons.

Keywords
  • Adolescent
  • Adult
  • B-Lymphocytes/immunology
  • Humans
  • Immunization, Secondary
  • Immunoglobulin A/blood/immunology
  • Immunoglobulin G/blood/immunology
  • Immunoglobulin M/blood/immunology
  • Immunologic Memory/immunology
  • Middle Aged
  • Plasma Cells/immunology
  • Rabies Vaccines/immunology
  • Vaccination
  • Young Adult
Citation (ISO format)
BLANCHARD ROHNER, Géraldine et al. Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans. In: Blood, 2009, vol. 114, n° 24, p. 4998–5002. doi: 10.1182/blood-2009-03-211052
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0006-4971
126views
133downloads

Technical informations

Creation02/02/2021 1:02:00 PM
First validation02/02/2021 1:02:00 PM
Update time03/16/2023 12:36:46 AM
Status update03/16/2023 12:36:46 AM
Last indexation01/17/2024 1:16:50 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack