Seroprevalence and placental transmission of maternal antibodies specific for Neisseria meningitidis Serogroups A, C, Y and W135 and influence of maternal antibodies on the immune response to a primary course of MenACWY-CRM vaccine in the United Kingdom

Blanchard Rohner, Géraldine; Snape, Matthew D; Kelly, Dominic F; O'Connor, Daniel; John, Tessa; Kibwana, Elizabeth; Parks, Hannah; Ford, Karen; Dull, Peter M; Pollard, Andrew J

doi:10.1097/INF.0b013e318292f425

Scientific article

English

Seroprevalence and placental transmission of maternal antibodies specific for Neisseria meningitidis Serogroups A, C, Y and W135 and influence of maternal antibodies on the immune response to a primary course of MenACWY-CRM vaccine in the United Kingdom

ContributorsBlanchard Rohner, Géraldine; Snape, Matthew D; Kelly, Dominic F; O'Connor, Daniel; John, Tessa; Kibwana, Elizabeth; Parks, Hannah; Ford, Karen; Dull, Peter M; Pollard, Andrew J

Published inPediatric Infectious Disease Journal, vol. 32, no. 7, p. 768-776

Publication date2013

Abstract

Maternal antibodies give neonates some protection against bacterial infection. We measured antibodies against Neisseria meningitidis serogroups A, C, Y and W135 in mothers and their 2-month-old infants at study enrollment. We also assessed the impact of maternal antibody present at 2 months of age on the immune response to a primary course of quadrivalent meningococcal conjugate vaccine (MenACWY-CRM197) given at 2 and 4 months of age.

Keywords

Antibodies, Bacterial/blood
B-Lymphocytes/chemistry/immunology
Female
Humans
Immunity, Maternally-Acquired
Immunologic Memory
Infant
Meningococcal Vaccines/administration & dosage/immunology
Neisseria meningitidis/immunology
Placenta/metabolism
Pregnancy
Seroepidemiologic Studies
United Kingdom
Vaccination/methods

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Recherche en infectiologie pédiatrique et en pédiatrie générale (853)

Citation (ISO format)

BLANCHARD ROHNER, Géraldine et al. Seroprevalence and placental transmission of maternal antibodies specific for Neisseria meningitidis Serogroups A, C, Y and W135 and influence of maternal antibodies on the immune response to a primary course of MenACWY-CRM vaccine in the United Kingdom. In: Pediatric Infectious Disease Journal, 2013, vol. 32, n° 7, p. 768–776. doi: 10.1097/INF.0b013e318292f425

Article (Published version)

Identifiers

PID : unige:151760
DOI : 10.1097/INF.0b013e318292f425
PMID : 23538521

Additional URL for this publicationhttps://journals.lww.com/pidj/Fulltext/2013/07000/Seroprevalence_and_Placental_Transmission_of.20.aspx

Journal ISSN0891-3668

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Seroprevalence and placental transmission of maternal antibodies specific for Neisseria meningitidis Serogroups A, C, Y and W135 and influence of maternal antibodies on the immune response to a primary course of MenACWY-CRM vaccine in the United Kingdom

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