Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?

Carrera, Emmanuel; Jones, P Simon; Alawneh, Josef A; Klærke Mikkelsen, Irene; Cho, Tae-Hee; Siemonsen, Suzanne; Guadagno, Joseph V; Mouridsen, Kim; Ribe, Lars; Hjort, Niels; Fryer, Tim D; Carpenter, T Adrian; Aigbirhio, Franklin I; Fiehler, Jens; Nighoghossian, Norbert; Warburton, Elizabeth A; Ostergaard, Leif; Baron, Jean-Claude

doi:10.1161/STROKEAHA.110.606970

Scientific article

English

Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?

ContributorsCarrera, Emmanuel; Jones, P Simon; Alawneh, Josef A; Klærke Mikkelsen, Irene; Cho, Tae-Hee; Siemonsen, Suzanne; Guadagno, Joseph V; Mouridsen, Kim; Ribe, Lars; Hjort, Niels; Fryer, Tim D; Carpenter, T Adrian; Aigbirhio, Franklin I; Fiehler, Jens; Nighoghossian, Norbert; Warburton, Elizabeth A; Ostergaard, Leif; Baron, Jean-Claude

Published inStroke, vol. 42, no. 6, p. 1602-1607

Publication date2011

Abstract

There is ample evidence that in anterior circulation stroke, the diffusion-weighted imaging (DWI) lesion may escape infarction and thus is not a reliable infarct predictor. In this study, we assessed the predictive value of the mean transit time (MTT) for final infarction within the DWI lesion, first in patients scanned back-to-back with 15O-positron emission tomography and MR (DWI and perfusion-weighted imaging; "Cambridge sample") within 7 to 21 hours of clinical onset, then in a large sample of patients with anterior circulation stroke receiving DWI and perfusion-weighted imaging within 12 hours (85% within 6 hours; "I-KNOW sample").

Keywords

Cerebral Infarction/pathology
Cerebrovascular Circulation/physiology
Diffusion Magnetic Resonance Imaging/methods
Humans
Prospective Studies
ROC Curve
Time Factors

Affiliation Not a UNIGE publication

Funding

European Commission - European Union Grant I-KNOW (027294)

Citation (ISO format)

CARRERA, Emmanuel et al. Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value? In: Stroke, 2011, vol. 42, n° 6, p. 1602–1607. doi: 10.1161/STROKEAHA.110.606970

Article (Published version)

Identifiers

PID : unige:151448
DOI : 10.1161/STROKEAHA.110.606970
PMID : 21512183

Commercial URLhttps://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.110.606970

ISSN of the journal0039-2499

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Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?

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