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Title

Brain intracrinology of allopregnanolone during pregnancy and hormonal contraception
Authors
Pluchino, Nicola
Ansaldi, Yveline Janine
Genazzani, Andrea R
Published in Hormone Molecular Biology and Clinical Investigation. 2019, vol. 37, no. 1, 20180032
Abstract Allopregnanolone (ALLO) has a crucial role in brain development and remodeling. Reproductive transitions associated with endocrine changes affect synthesis and activity of ALLO with behavioral/affective consequences. Pregnancy is characterized by an increased synthesis of progesterone/ALLO by the placenta, maternal and fetal brains. This suggests the critical role of these steroids in maternal brain adaptation during pregnancy and the development of the fetal brain. ALLO is brain protective during complications of pregnancy, such as preterm delivery or intrauterine growth restriction (IUGR), reducing the impact of hypoxia, and excitotoxic brain damage. Negative behavioral consequences of altered progesterone/ALLO maternal brain adaptation have been also hypothesized in the post-partum and targeting ALLO is a promising treatment. Hormonal contraception may alter ALLO action, although the effects are mostly related to a specific class of progestins. Understanding the interactions between ALLO and the endocrine environment is crucial for more effective and tailored hormonal treatments.
Keywords Brain/drug effects/embryology/growth & development — Contraceptive Agents, Female/administration & dosage — Female — Fetal Development/drug effects — Humans — Maternal Exposure — Organogenesis/drug effects — Pregnancy — Pregnanolone/administration & dosage/metabolism — Progestins/administration & dosage
Identifiers
PMID: 30739099
Full text
Article (Published version) (313 Kb) - public document Free access
Other version: https://www.degruyter.com/document/doi/10.1515/hmbci-2018-0032/html
Structures
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group Groupe Petignat Patrick (933)
Citation
(ISO format) 		PLUCHINO, Nicola, ANSALDI, Yveline Janine, GENAZZANI, Andrea R. Brain intracrinology of allopregnanolone during pregnancy and hormonal contraception. In: Hormone Molecular Biology and Clinical Investigation, 2019, vol. 37, n° 1, p. 20180032. doi: 10.1515/hmbci-2018-0032 https://archive-ouverte.unige.ch/unige:151359

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Deposited on : 2021-04-30

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