Objective. The use of a 30μm alumina–silica coated particle sand (CoJetTM Sand, 3M Espe), has shown to enhance the adhesion of resin cements to Y-TZP. The question is whether or not sandblasting 30μm particles does negatively affect the fatigue limit (S–N curves) and the cumulative survival of Y-TZP ceramics. Method. Four zirconia materials tested were: Zeno (ZW) (Wieland), Everest ZS (KV) (KaVo), Lava white (LV) and Lava colored (LVB) (3M Espe). Fatigue testing (S–N) was performed on 66 bar of 3mm×5mm×40mm with beveled edges for each zirconia material provided by the manufacturers. One half of the specimens were CoJet sandblasted in the middle of the tensile side on a surface of 5mm×6mm. Cyclic fatigue (N= 30/group) (sinusoidal loading/ unloading at 10 Hz between 10% and 100% load) was performed in 3-point-bending in a water tank. Stress levels were lowered from the initial static value (average of N= 3) until surviving 1 million cycles. Fatigue limits were determined from trend lines. Kaplan–Meier survival analysis was performed to determine the failure stress at the median percentile survival level for 1 million of cycles before and after sandblasting. The statistical analyses used the log-rank test. Characterization of the critical flaw was performed by SEM for the majority of the failed specimens. Results. The fatigue limits “as received” (ctr) were: LV= 720MPa, LVB = 600MPa, KV= 560MPa, ZW= 470MPa. The fatigue limits “after CoJet sandblasting”were: LV= 840MPa, LVB = 788MPa, KV= 645MPa,ZW= 540MPa. The increase in fatigue limit after sandblastingwas 15% for Zeno (ZW) and Everest (KV), 17% for Lava (LV) and 31% for Lava colored (LVB). The KM median survival stresses in MPa were: ZW(ctr) = 549 (543–555), ZW(s) = 587 (545–629), KV(ctr) = 593 (579–607), KV(s) = 676 (655–697), LVB(ctr) = 635 (578–692), LVB(s) = 809 (787–831), LV(ctr) = 743 (729–757), LV(s) = 908 (840–976). Log-rank tests were significantly different (p < 0.001) for all sandblasted groups vs. the “as received” except for Zeno (Wieland) (p = 0.295). Failures started from both intrinsic and machined flaws. Significance. 30μm particle sandblasting did significantly improve the fatigue behavior of three out of four Y-TZP ceramic materials and can therefore be recommended for adhesive cementation procedures.