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Scientific article
English

A new DR7-DQ8 haplotype resulting from a recombination between the DQA1 and DQB1 loci in a leukemic patient of Caucasoid origin

Contributors

Tiercy, Jean-Marie; Villard, Jean

Published in

Immunogenetics, vol. 56, no. 4, p. 301-303

Publication date

2004

Abstract

Meiotic recombinations within the HLA-DR/DQ subregion are seldomly observed. However the high number of unusual DRB1-DQB1 allelic combinations underline the importance of crossover in shaping the class II haplotypic diversity. We present here the first report of a DQA1-DQB1 recombination event in a leukemic patient as detected by complete class II molecular typing of the family, including analysis of the DQCAR microsatellite. The recombination that occurred on the maternal chromosomes led to the unusual DR7-DQ8 haplotype characterized by the DRB1*0701-DRB4*01030102N-DQA1*0201-DQB1*0302 alleles. Because the patient had no HLA-identical sibling donor, a search for an unrelated hematopoietic stem cell donor was initiated. Out of three potential donors, only one HLA-A/-B/-C/DRB1-compatible but DQB1-mismatched donor could be identified.

Keywords

  • Acute Disease
  • European Continental Ancestry Group
  • Female
  • HLA-DQ Antigens/genetics
  • HLA-DQ alpha-Chains
  • HLA-DQ beta-Chains
  • Haplotypes/genetics
  • Hematopoietic Stem Cell Transplantation
  • Histocompatibility Testing
  • Humans
  • Leukemia
  • Myeloid/genetics/therapy
  • Male
  • Meiosis/genetics
  • Microsatellite Repeats
  • Recombination
  • Genetic
  • Siblings
  • Tissue Donors

UNIGE affiliation entities

UNIGE research groups

Funding

  • Swiss National Science Foundation - Human hematopoietic stem cell transplantation: involvement of immunogenetic factors in allorecognition by cytotoxic T lympho- cytes

Citation (ISO format)

TIERCY, Jean-Marie, VILLARD, Jean. A new DR7-DQ8 haplotype resulting from a recombination between the DQA1 and DQB1 loci in a leukemic patient of Caucasoid origin. In: Immunogenetics, 2004, vol. 56, n° 4, p. 301–303. doi: 10.1007/s00251-004-0678-x

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0093-7711
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Technical informations

Creation

26/10/2020 15:02:00

First validation

26/10/2020 15:02:00

Update

14/11/2024 14:51:13

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