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Scientific article
English

Mouse Alpha-amylase Loci, Amy-1a and Amy-2a, are Closely Linked

Contributors

Pittet, Anne-Cécile; Schibler, Ulrich

Published in

Journal of Molecular Biology, vol. 182, no. 3, p. 359-365

Publication date

1985

Abstract

We have cloned a contiguous 106×10³ base-pair long stretch of mouse DNA. The isolated chromosomal DNA segment contains the single copy gene Amy-1a that is strongly expressed in the parotid gland and, 23×10³ base-pairs downstream from it, one member of the pancreas-specific Amy-2a oligogene family. At least two of the four Amy-2a genes, including the copy linked to Amy-1a, are efficiently transcribed. The cloned DNA sequences do not appear to specify messenger RNAs other than those encoding alpha-amylase in pancreas, parotid gland or liver. Transcription termination on Amy-1a occurs within 3×10³ base-pairs downstream from the polyadenylation site in both parotid gland and liver, in which this gene is transcribed at different rates from different promoters.

UNIGE affiliation entities

Not a UNIGE publication

Funding

  • Swiss National Science Foundation - 3.410.83

Citation (ISO format)

PITTET, Anne-Cécile, SCHIBLER, Ulrich. Mouse Alpha-amylase Loci, Amy-1a and Amy-2a, are Closely Linked. In: Journal of Molecular Biology, 1985, vol. 182, n° 3, p. 359–365. doi: 10.1016/0022-2836(85)90196-2

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

https://linkinghub.elsevier.com/retrieve/pii/0022283685901962

Journal ISSN

0022-2836
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Technical informations

Creation

25/03/2021 09:56:00

First validation

25/03/2021 09:56:00

Update

16/03/2023 00:21:07

Status update

16/03/2023 00:21:06

Last indexation

31/10/2024 21:45:26
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