New findings demonstrate that endothelial nitric oxide synthase regulates major metabolic pathways in the kidney proximal tubule, which confers protection against oxidative stress during acute kidney injury (AKI). These findings give new insights into AKI pathophysiology and nitric oxide biology , and identify new targets for the treatment of AKI. // Refers to Zhou, H.-L. et al. Metabolic reprogramming by the S- nitroso-CoA reductase system protects against kidney injury. Nature565, 96–100 (2018)