Scientific article
Open access

Increased oxytocin release precedes hyponatremia after pituitary surgery

Published inPituitary
Publication date2021

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a well-known complication of transsphenoidal pituitary surgery, related to inappropriate secretion of arginine vasopressin (AVP). Its diagnosis is based on hyponatremia, with a peak of occurrence around day 7 after surgery and, to date, no early marker has been reported. In particular, copeptin levels are not predictive of hyponatremia in this case. Oxytocin (OXT) is secreted into the peripheral blood by axon terminals adjacent to those of AVP neurons in the posterior pituitary. Besides its role in childbirth and lactation, recent evidences suggested a role for OXT in sodium balance. The contribution of this hormone in the dysnatremias observed after pituitary surgery has however never been investigated.

  • Hyponatremia
  • Neurosurgery
  • Oxytocin
  • Pituitary gland
Citation (ISO format)
CONSTANTHIN, Paul et al. Increased oxytocin release precedes hyponatremia after pituitary surgery. In: Pituitary, 2021. doi: 10.1007/s11102-020-01121-4
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ISSN of the journal1386-341X

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