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Title

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing

Authors
Lima, John J
Thomas, Cameron D
Barbarino, Julia
Desta, Zeruesenay
Van Driest, Sara L
El Rouby, Nihal
Johnson, Julie A
Cavallari, Larisa H
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Published in Clinical Pharmacology and Therapeutics. 2020
Abstract Proton pump inhibitors (PPIs) are widely used for acid suppression in the treatment and prevention of many conditions, including gastroesophageal reflux disease, gastric and duodenal ulcers, erosive esophagitis, Helicobacter pylori infection, and pathological hypersecretory conditions. Most PPIs are metabolized primarily by cytochrome P450 2C19 (CYP2C19) into inactive metabolites, and CYP2C19 genotype has been linked to PPI exposure, efficacy, and adverse effects. We summarize the evidence from the literature and provide therapeutic recommendations for PPI prescribing based on CYP2C19 genotype (updates at www.cpicpgx.org). The potential benefits of using CYP2C19 genotype data to guide PPI therapy include (i) identifying patients with genotypes predictive of lower plasma exposure and prescribing them a higher dose that will increase the likelihood of efficacy, and (ii) identifying patients on chronic therapy with genotypes predictive of higher plasma exposure and prescribing them a decreased dose to minimize the risk of toxicity that is associated with long-term PPI use, particularly at higher plasma concentrations.
Identifiers
PMID: 32770672
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Article (Published version) (168 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Project H2020: UPGx grant 668353
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LIMA, John J et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing. In: Clinical Pharmacology and Therapeutics, 2020. doi: 10.1002/cpt.2015 https://archive-ouverte.unige.ch/unige:150660

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Deposited on : 2021-03-26

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