RACE-trial: neoadjuvant radiochemotherapy versus chemotherapy for patients with locally advanced, potentially resectable adenocarcinoma of the gastroesophageal junction - a randomized phase III joint study of the AIO, ARO and DGAV

Lorenzen, Sylvie; Biederstädt, Alexander; Ronellenfitsch, Ulrich; Reißfelder, Christoph; Moenig, Stefan Paul; Wenz, Frederik; Pauligk, Claudia; Walker, Martin; Al-Batran, Salah-Eddin; Haller, Bernhard; Hofheinz, Ralf-Dieter

doi:10.1186/s12885-020-07388-x

Scientific article

English

RACE-trial: neoadjuvant radiochemotherapy versus chemotherapy for patients with locally advanced, potentially resectable adenocarcinoma of the gastroesophageal junction - a randomized phase III joint study of the AIO, ARO and DGAV

Contributors

Lorenzen, Sylvie; Biederstädt, Alexander; Ronellenfitsch, Ulrich; Reißfelder, Christoph; Moenig, Stefan Paul; Wenz, Frederik; Pauligk, Claudia; Walker, Martin; Al-Batran, Salah-Eddin; Haller, Bernhard; Hofheinz, Ralf-Dieter

Published in

BMC Cancer, vol. 20, no. 1, 886

Publication date

2020

Abstract

Despite obvious advances over the last decades, locally advanced adenocarcinomas of the gastroesophageal junction (GEJ) still carry a dismal prognosis with overall 5-year survival rates of less than 50% even when using modern optimized treatment protocols such as perioperative chemotherapy based on the FLOT regimen or radiochemotherapy. Therefore the question remains whether neoadjuvant chemotherapy or neoadjuvant radiochemotherapy is eliciting the best results in patients with GEJ cancer. Hence, an adequately powered multicentre trial comparing both therapeutic strategies is clearly warranted.

Keywords

FLOT
Locally advanced adenocarcinoma of the gastroesophageal junction
Neoadjuvant radiochemotherapy
Perioperative chemotherapy

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

UNIGE research groups

Transplantation et hépatologie (905)

Citation (ISO format)

LORENZEN, Sylvie et al. RACE-trial: neoadjuvant radiochemotherapy versus chemotherapy for patients with locally advanced, potentially resectable adenocarcinoma of the gastroesophageal junction - a randomized phase III joint study of the AIO, ARO and DGAV. In: BMC Cancer, 2020, vol. 20, n° 1, p. 886. doi: 10.1186/s12885-020-07388-x

Article (Published version)

CC BY

Identifiers

PID : unige:150615
DOI : 10.1186/s12885-020-07388-x
PMID : 32933498

Additional URL for this publication

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493344/

Journal ISSN

1471-2407

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228downloads

Creation

14/01/2021 11:58:00

First validation

14/01/2021 11:58:00

Update

16/03/2023 00:18:56

Status update

16/03/2023 00:18:55

Last indexation

31/10/2024 21:41:49

RACE-trial: neoadjuvant radiochemotherapy versus chemotherapy for patients with locally advanced, potentially resectable adenocarcinoma of the gastroesophageal junction - a randomized phase III joint study of the AIO, ARO and DGAV

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

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Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation