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Scientific article
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English

Neutralization of S100A4 induces stabilization of atherosclerotic plaques: role of smooth muscle cells

Published inCardiovascular Research, vol. 118, no. 1, p. 141-155
Publication date2022
Abstract

During atherosclerosis, smooth muscle cells (SMCs) accumulate in the intima where they switch from a contractile to a synthetic phenotype. From porcine coronary artery, we isolated spindle-shaped (S) SMCs exhibiting features of the contractile phenotype and rhomboid (R) SMCs typical of the synthetic phenotype. S100A4 was identified as a marker of R-SMCs in vitro and intimal SMCs, in pig and man. S100A4 exhibits intra- and extracellular functions. In this study, we investigated the role of extracellular S100A4 in SMC phenotypic transition.

Citation (ISO format)
SAKIC, Antonija et al. Neutralization of S100A4 induces stabilization of atherosclerotic plaques: role of smooth muscle cells. In: Cardiovascular Research, 2022, vol. 118, n° 1, p. 141–155. doi: 10.1093/cvr/cvaa311
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ISSN of the journal0008-6363
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Creation03/21/2021 4:56:00 PM
First validation03/21/2021 4:56:00 PM
Update time03/16/2023 12:17:52 AM
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