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Title

Neutralization of S100A4 induces stabilization of atherosclerotic plaques: role of smooth muscle cells

Authors
Ambartsumian, N
Klingelhöfer, J
Grigorian, M
Published in Cardiovascular Research. 2020
Abstract During atherosclerosis, smooth muscle cells (SMCs) accumulate in the intima where they switch from a contractile to a synthetic phenotype. From porcine coronary artery, we isolated spindle-shaped (S) SMCs exhibiting features of the contractile phenotype and rhomboid (R) SMCs typical of the synthetic phenotype. S100A4 was identified as a marker of R-SMCs in vitro and intimal SMCs, in pig and man. S100A4 exhibits intra- and extracellular functions. In this study, we investigated the role of extracellular S100A4 in SMC phenotypic transition.
Identifiers
PMID: 33135065
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Structures
Research groups L'athérosclérose (665)
Bochaton-Piallat Marie-Luce (pathologie et immunologie) (646)
Project
FNS: 310030_185370/1
Citation
(ISO format)
SAKIC, Antonija et al. Neutralization of S100A4 induces stabilization of atherosclerotic plaques: role of smooth muscle cells. In: Cardiovascular Research, 2020. doi: 10.1093/cvr/cvaa311 https://archive-ouverte.unige.ch/unige:150557

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Deposited on : 2021-03-22

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