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Investigation of large-scale epileptic networks in rodent models of focal epilepsy

Defense Thèse de privat-docent : Univ. Genève, 2020
Abstract This Privat Docent thesis presents three of my recent studies that explore the development and the mechanisms of large-scale epileptic networks in the kainate mouse model of TLE using high density EEG combined to multiple intracerebral recordings. We reveal that a large-scale epileptic network develops and invade both hemispheres, generating epileptic patterns and altering functional connectivity at the whole brain level. We further show that low frequency synchronization and cross frequency coupling are key mechanisms at works in these large-scale pathologic networks. To introduce these works, I first discuss the fundamental, clinical and translational scientific contributions summarizing current knowledge and providing new insight on the large-scale aspects of focal epilepsies, with a particular focus on mesial temporal lobe epilepsies.
Keywords EpilepsyFocal epilepsyLarge-scale networkEEGLFPKainate
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Thesis (39.7 MB) - public document Free access
Research group Organisation et plasticité des réseaux neuronaux cérébraux (148)
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QUAIRIAUX, Charles. Investigation of large-scale epileptic networks in rodent models of focal epilepsy. Université de Genève. Thèse de privat-docent, 2020. doi: 10.13097/archive-ouverte/unige:150477 https://archive-ouverte.unige.ch/unige:150477

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Deposited on : 2021-03-18

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