The DNA Sequence Change Resulting from the <i>I<sup>Q1</sup></i> Mutation, which Greatly Increases Promoter Strength

Calos, Michèle P.; Miller, Jeffrey H.

doi:10.1007/BF00268783

Scientific article

English

The DNA Sequence Change Resulting from the I^Q1 Mutation, which Greatly Increases Promoter Strength

ContributorsCalos, Michèle P.; Miller, Jeffrey H.

Published inMolecular and General Genetics, vol. 183, no. 3, p. 559-560

Publication date1981

Abstract

DNA sequencing shows that the mutational alteration resulting from IQ1 is a deletion of 15 base pairs in the lacI promoter. The deletion creates a greatly improved — 35 homology region, explaining the 50–100-fold increase in lac repressor synthesis.

Affiliation entities

Faculté des sciences / Section de biologie / Département de biologie moléculaire

Funding

Swiss National Science Foundation - 3.493.0.79

Citation (ISO format)

CALOS, Michèle P., MILLER, Jeffrey H. The DNA Sequence Change Resulting from the I^Q1 Mutation, which Greatly Increases Promoter Strength. In: Molecular and General Genetics, 1981, vol. 183, n° 3, p. 559–560. doi: 10.1007/BF00268783

Article (Published version)

CC BY

Identifiers

PID : unige:150441
DOI : 10.1007/BF00268783

Commercial URLhttp://link.springer.com/10.1007/BF00268783

Journal ISSN0026-8925

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The DNA Sequence Change Resulting from the IQ1 Mutation, which Greatly Increases Promoter Strength

DNA sequencing shows that the mutational alteration resulting from IQ1 is a deletion of 15 base pairs in the lacI promoter. The deletion creates a greatly improved — 35 homology region, explaining the 50–100-fold increase in lac repressor synthesis.

Technical informations

The DNA Sequence Change Resulting from the I^Q1 Mutation, which Greatly Increases Promoter Strength